Unwinding the Role of FACT in Cas9-based Genome Editing.

Journal Article (Journal Article)

In a recent issue of Molecular Cell, Wang et al. (2020) employ unbiased proteomics approaches and live-cell imaging to reveal a key role for the histone chaperone complex FACT (SPT16 and SSRP1) in governing Cas9 turnover at the DNA target site during genome and epigenome editing.

Full Text

Duke Authors

Cited Authors

  • Cosgrove, BD; Gersbach, CA

Published Date

  • August 2020

Published In

Volume / Issue

  • 79 / 3

Start / End Page

  • 365 - 367

PubMed ID

  • 32763224

Pubmed Central ID

  • 32763224

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2020.07.016

Language

  • eng