Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses.
Journal Article (Journal Article)
Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
Full Text
Duke Authors
Cited Authors
- Prasanth, KR; Hirano, M; Fagg, WS; McAnarney, ET; Shan, C; Xie, X; Hage, A; Pietzsch, CA; Bukreyev, A; Rajsbaum, R; Shi, P-Y; Bedford, MT; Bradrick, SS; Menachery, V; Garcia-Blanco, MA
Published Date
- October 2020
Published In
Volume / Issue
- 182 /
Start / End Page
- 104874 -
PubMed ID
- 32735900
Pubmed Central ID
- PMC7386308
Electronic International Standard Serial Number (EISSN)
- 1872-9096
Digital Object Identifier (DOI)
- 10.1016/j.antiviral.2020.104874
Language
- eng
Conference Location
- Netherlands