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Harnessing virus tropism for dendritic cells for vaccine design.

Publication ,  Journal Article
Mosaheb, MM; Brown, MC; Dobrikova, EY; Dobrikov, MI; Gromeier, M
Published in: Curr Opin Virol
October 2020

Dendritic cells (DCs) are pivotal stimulators of T cell responses. They provide essential signals (epitope presentation, proinflammatory cytokines, co-stimulation) to T cells and prime adaptive immunity. Therefore, they are paramount to immunization strategies geared to generate T cell immunity. The inflammatory signals DCs respond to, classically occur in the context of acute virus infection. Yet, enlisting viruses for engaging DCs is hampered by their penchant for targeting DCs with sophisticated immune evasive and suppressive ploys. In this review, we discuss our work on devising vectors based on a recombinant polio:rhinovirus chimera for effectively targeting and engaging DCs. We are juxtaposing this approach with commonly used, recently studied dsDNA virus vector platforms.

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Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

October 2020

Volume

44

Start / End Page

73 / 80

Location

Netherlands

Related Subject Headings

  • Viral Vaccines
  • Viral Tropism
  • T-Lymphocytes
  • Poliovirus
  • Mice
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Genetic Vectors
  • Dendritic Cells
 

Citation

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Mosaheb, M. M., Brown, M. C., Dobrikova, E. Y., Dobrikov, M. I., & Gromeier, M. (2020). Harnessing virus tropism for dendritic cells for vaccine design. Curr Opin Virol, 44, 73–80. https://doi.org/10.1016/j.coviro.2020.07.012
Mosaheb, Mubeen M., Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Harnessing virus tropism for dendritic cells for vaccine design.Curr Opin Virol 44 (October 2020): 73–80. https://doi.org/10.1016/j.coviro.2020.07.012.
Mosaheb MM, Brown MC, Dobrikova EY, Dobrikov MI, Gromeier M. Harnessing virus tropism for dendritic cells for vaccine design. Curr Opin Virol. 2020 Oct;44:73–80.
Mosaheb, Mubeen M., et al. “Harnessing virus tropism for dendritic cells for vaccine design.Curr Opin Virol, vol. 44, Oct. 2020, pp. 73–80. Pubmed, doi:10.1016/j.coviro.2020.07.012.
Mosaheb MM, Brown MC, Dobrikova EY, Dobrikov MI, Gromeier M. Harnessing virus tropism for dendritic cells for vaccine design. Curr Opin Virol. 2020 Oct;44:73–80.
Journal cover image

Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

October 2020

Volume

44

Start / End Page

73 / 80

Location

Netherlands

Related Subject Headings

  • Viral Vaccines
  • Viral Tropism
  • T-Lymphocytes
  • Poliovirus
  • Mice
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Genetic Vectors
  • Dendritic Cells