Harnessing virus tropism for dendritic cells for vaccine design.

Journal Article (Journal Article;Review)

Dendritic cells (DCs) are pivotal stimulators of T cell responses. They provide essential signals (epitope presentation, proinflammatory cytokines, co-stimulation) to T cells and prime adaptive immunity. Therefore, they are paramount to immunization strategies geared to generate T cell immunity. The inflammatory signals DCs respond to, classically occur in the context of acute virus infection. Yet, enlisting viruses for engaging DCs is hampered by their penchant for targeting DCs with sophisticated immune evasive and suppressive ploys. In this review, we discuss our work on devising vectors based on a recombinant polio:rhinovirus chimera for effectively targeting and engaging DCs. We are juxtaposing this approach with commonly used, recently studied dsDNA virus vector platforms.

Full Text

Duke Authors

Cited Authors

  • Mosaheb, MM; Brown, MC; Dobrikova, EY; Dobrikov, MI; Gromeier, M

Published Date

  • October 2020

Published In

Volume / Issue

  • 44 /

Start / End Page

  • 73 - 80

PubMed ID

  • 32771959

Pubmed Central ID

  • PMC7755660

Electronic International Standard Serial Number (EISSN)

  • 1879-6265

Digital Object Identifier (DOI)

  • 10.1016/j.coviro.2020.07.012

Language

  • eng

Conference Location

  • Netherlands