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Cytomegalovirus as an immunomodulator across the lifespan.

Publication ,  Journal Article
Semmes, EC; Hurst, JH; Walsh, KM; Permar, SR
Published in: Curr Opin Virol
October 2020

Human cytomegalovirus (HCMV) is a nearly ubiquitous β-herpesvirus that establishes latent infection in the majority of the world's population. HCMV infection profoundly influences the host immune system and, perhaps more than any other human pathogen, has been shown to create a lasting imprint on human T and NK cell compartments. HCMV-seropositivity has been associated with both beneficial effects, such as increased vaccine responsiveness or heterologous protection against infections, and deleterious effects, such as pathological neurodevelopmental sequelae from congenital infection in utero and cumulative damage from chronic lifelong latency into old age. The significance of many of these associations is unclear, as studies into the causal mechanisms linking HCMV and these disease outcomes are lacking; however, HCMV-mediated changes to the immune system may play a key role. This review examines how HCMV impacts the host immune system in an age-dependent manner with important implications for human immunophenotypes and long-term disease risk.

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Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

October 2020

Volume

44

Start / End Page

112 / 120

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes
  • Risk Factors
  • Mice
  • Longevity
  • Killer Cells, Natural
  • Immunologic Factors
  • Humans
  • Cytomegalovirus Infections
  • Cytomegalovirus
  • Animals
 

Citation

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Semmes, E. C., Hurst, J. H., Walsh, K. M., & Permar, S. R. (2020). Cytomegalovirus as an immunomodulator across the lifespan. Curr Opin Virol, 44, 112–120. https://doi.org/10.1016/j.coviro.2020.07.013
Semmes, Eleanor C., Jillian H. Hurst, Kyle M. Walsh, and Sallie R. Permar. “Cytomegalovirus as an immunomodulator across the lifespan.Curr Opin Virol 44 (October 2020): 112–20. https://doi.org/10.1016/j.coviro.2020.07.013.
Semmes EC, Hurst JH, Walsh KM, Permar SR. Cytomegalovirus as an immunomodulator across the lifespan. Curr Opin Virol. 2020 Oct;44:112–20.
Semmes, Eleanor C., et al. “Cytomegalovirus as an immunomodulator across the lifespan.Curr Opin Virol, vol. 44, Oct. 2020, pp. 112–20. Pubmed, doi:10.1016/j.coviro.2020.07.013.
Semmes EC, Hurst JH, Walsh KM, Permar SR. Cytomegalovirus as an immunomodulator across the lifespan. Curr Opin Virol. 2020 Oct;44:112–120.
Journal cover image

Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

October 2020

Volume

44

Start / End Page

112 / 120

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes
  • Risk Factors
  • Mice
  • Longevity
  • Killer Cells, Natural
  • Immunologic Factors
  • Humans
  • Cytomegalovirus Infections
  • Cytomegalovirus
  • Animals