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Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease.

Publication ,  Journal Article
Pinheiro, MVT; Moll-Bernardes, RJ; Camargo, GC; Siqueira, FP; Azevedo, CFD; Holanda, MTD; Mendes, FDSNS; Sangenis, LHC; Mediano, MFF; Sousa, ASD
Published in: The American journal of tropical medicine and hygiene
August 2020

Chronic Chagas disease can progress to myocardial involvement with intense fibrosis, which may predispose patients to sudden cardiac death through ventricular arrhythmia. The associations of myocardial fibrosis detected by cardiac magnetic resonance (CMR) parameters with non-sustained ventricular tachycardia (NSVT) were evaluated. This cross-sectional study included patients in early stages of Chagas disease (n = 47) and a control group (n = 15). Patients underwent cardiac evaluation, including CMR examination. Myocardial fibrosis assessment by CMR with measurement of late gadolinium enhancement (LGE), native T1, and extracellular volume (ECV) was performed. There was an increase in myocardial fibrosis CMR parameters and ventricular arrhythmias among different stages of Chagas disease, combined with a decrease in the left ventricular ejection fraction (LVEF) by CMR and also in the right ventricular systolic function by S' wave on tissue Doppler. Fibrosis mass and ECV were associated with the Rassi score, ventricular extrasystole, and E/e' ratio in a logistic regression model adjusted for age and gender. The ECV maintained an association with the presence of NSVT, even after adjustments for fibrosis mass and LVEF assessed by CMR. The receiver-operating characteristic area under the curve for global ECV (0.85; 95% CI: 0.71-0.99) and NSVT was greater than that for fibrosis mass (0.75; 95% CI: 0.54-0.96), although this difference was not statistically significant. Extracellular volume could be an early marker of increased risk of ventricular arrhythmia in Chagas disease, presenting an independent association with NSVT in the initial stages of chronic Chagas cardiomyopathy, even after adjustment for fibrosis mass and LVEF.

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Published In

The American journal of tropical medicine and hygiene

DOI

EISSN

1476-1645

ISSN

0002-9637

Publication Date

August 2020

Volume

103

Issue

2

Start / End Page

745 / 751

Related Subject Headings

  • Ventricular Function, Right
  • Tropical Medicine
  • Tachycardia, Ventricular
  • Stroke Volume
  • ROC Curve
  • Organ Size
  • Myocardium
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
 

Citation

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Pinheiro, M. V. T., Moll-Bernardes, R. J., Camargo, G. C., Siqueira, F. P., Azevedo, C. F. D., Holanda, M. T. D., … Sousa, A. S. D. (2020). Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease. The American Journal of Tropical Medicine and Hygiene, 103(2), 745–751. https://doi.org/10.4269/ajtmh.20-0122
Pinheiro, Martha Valéria Tavares, Renata Junqueira Moll-Bernardes, Gabriel Cordeiro Camargo, Fabio Paiva Siqueira, Clerio Francisco de Azevedo, Marcelo Teixeira de Holanda, Fernanda de Souza Nogueira Sardinha Mendes, Luiz Henrique Conde Sangenis, Mauro Felippe Felix Mediano, and Andréa Silvestre de Sousa. “Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease.The American Journal of Tropical Medicine and Hygiene 103, no. 2 (August 2020): 745–51. https://doi.org/10.4269/ajtmh.20-0122.
Pinheiro MVT, Moll-Bernardes RJ, Camargo GC, Siqueira FP, Azevedo CFD, Holanda MTD, et al. Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease. The American journal of tropical medicine and hygiene. 2020 Aug;103(2):745–51.
Pinheiro, Martha Valéria Tavares, et al. “Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease.The American Journal of Tropical Medicine and Hygiene, vol. 103, no. 2, Aug. 2020, pp. 745–51. Epmc, doi:10.4269/ajtmh.20-0122.
Pinheiro MVT, Moll-Bernardes RJ, Camargo GC, Siqueira FP, Azevedo CFD, Holanda MTD, Mendes FDSNS, Sangenis LHC, Mediano MFF, Sousa ASD. Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease. The American journal of tropical medicine and hygiene. 2020 Aug;103(2):745–751.

Published In

The American journal of tropical medicine and hygiene

DOI

EISSN

1476-1645

ISSN

0002-9637

Publication Date

August 2020

Volume

103

Issue

2

Start / End Page

745 / 751

Related Subject Headings

  • Ventricular Function, Right
  • Tropical Medicine
  • Tachycardia, Ventricular
  • Stroke Volume
  • ROC Curve
  • Organ Size
  • Myocardium
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine