Synchronous Abdominal Wall and Small-bowel Transplantation: A 1-year Follow-up.

Journal Article (Journal Article)

Abdominal wall-vascularized composite allotransplantation (AW-VCA) has evolved as a technically feasible but challenging option in the rare event of abdominal wall reconstruction in patients whose abdomen cannot be closed by applying conventional methods. The authors conducted the first synchronous child-to-adult recipient AW-VCA using an arteriovenous loop technique. This article presents a 1-year follow-up of the patient's postoperative course. Frequent skin biopsies were performed in accordance with Duke Institutional Review Board protocol, with 3 episodes of rejection treated with high-dose steroids and Thymoglobulin (Genzyme Corp, Cambridge, Mass.). The patient developed an opportunistic fungal brain abscess secondary to immunosuppression, which led to temporary upper extremity weakness. Future considerations for AW-VCA include a modified surgical technique involving utilization of donor vein graft for arteriovenous loop formation. In addition, reduction in postoperative biopsy schedule and changes in immunosuppression regimen may lead to improved outcomes and prevent unnecessary high-dose immunosuppression.

Full Text

Duke Authors

Cited Authors

  • Atia, A; Hollins, A; Erdmann, RF; Shammas, R; Sudan, DL; Mithani, SK; Ravindra, KV; Erdmann, D

Published Date

  • July 2020

Published In

Volume / Issue

  • 8 / 7

Start / End Page

  • e2995 -

PubMed ID

  • 32802681

Pubmed Central ID

  • PMC7413814

International Standard Serial Number (ISSN)

  • 2169-7574

Digital Object Identifier (DOI)

  • 10.1097/GOX.0000000000002995


  • eng

Conference Location

  • United States