RSSs set the odds for exclusion.

Journal Article (Journal Article)

In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.

Full Text

Duke Authors

Cited Authors

  • Krangel, MS

Published Date

  • September 7, 2020

Published In

Volume / Issue

  • 217 / 9

PubMed ID

  • 32793983

Pubmed Central ID

  • PMC7478726

Electronic International Standard Serial Number (EISSN)

  • 1540-9538

Digital Object Identifier (DOI)

  • 10.1084/jem.20200831

Language

  • eng

Conference Location

  • United States