Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.

Journal Article (Journal Article)

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD. A total of 37 patients with PAD and 29 control subjects performed cardiopulmonary exercise testing on a treadmill for AT and gastrocnemius muscle biopsies. Skeletal muscle capillary density was measured using immunofluorescence staining. PAD had decreased capillary density (278 ± 87 vs 331 ± 86 endothelial cells/mm2, p = 0.05), peak VO2 (15.7 ± 3.9 vs 24.3 ± 5.2 mL/kg/min, p ⩽ 0.001), and VO2 at AT (11.5 ± 2.6 vs 16.1 ± 2.8 mL/kg/min, p ⩽ 0.001) compared to control subjects. In patients with PAD, but not control subjects, capillary density was related to VO2 at AT (r = 0.343; p = 0.038), time to AT (r = 0.381; p = 0.020), and time after AT to test termination (r = 0.610; p ⩽ 0.001). Capillary density was also related to time to claudication (r = 0.332; p = 0.038) and time after claudication to test termination (r = 0.584; p ⩽ 0.001). In conclusion, relationships between capillary density, AT, and claudication symptoms indicate that, in PAD, exercise limitations are likely partially dependent on limited skeletal muscle capillary density and oxidative metabolism.

Full Text

Duke Authors

Cited Authors

  • Duscha, BD; Kraus, WE; Jones, WS; Robbins, JL; Piner, LW; Huffman, KM; Allen, JD; Annex, BH

Published Date

  • October 2020

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 411 - 418

PubMed ID

  • 32841100

Pubmed Central ID

  • PMC8297535

Electronic International Standard Serial Number (EISSN)

  • 1477-0377

Digital Object Identifier (DOI)

  • 10.1177/1358863X20945794

Language

  • eng

Conference Location

  • England