Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC

Journal Article

Abstract Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based compounds interact with isolated DNA in vitro, it is unclear what effect these compounds exert in cells. Moreover, the antibiotic efficacy of polynuclear ruthenium organometallic compounds remains uncertain. In the present study, we report that exposure to polynuclear ruthenium organometallic compounds induces recruitment of damaged DNA sensing protein Xeroderma pigmentosum Group C into chromatin-immobilized foci. Additionally, we observed one of the tested polynuclear ruthenium organometallic compounds displayed increased cytotoxicity against human cells deficient in nucleotide excision repair (NER). Taken together, these results suggest that polynuclear ruthenium organometallic compounds induce DNA damage in cells, and that cellular resistance to these compounds may be influenced by the NER DNA repair phenotype of the cells.

Full Text

Duke Authors

Cited Authors

  • Fast, OG; Gentry, B; Strouth, L; Niece, MB; Beckford, FA; Shell, SM

Published Date

  • July 31, 2019

Published In

Volume / Issue

  • 39 / 7

Published By

Electronic International Standard Serial Number (EISSN)

  • 1573-4935

International Standard Serial Number (ISSN)

  • 0144-8463

Digital Object Identifier (DOI)

  • 10.1042/bsr20190378

Language

  • en