Fatal respiratory infection due to ST308 VIM-1-producing Pseudomonas aeruginosa in a lung transplant recipient: case report and review of the literature.

Published online

Journal Article (Review)

BACKGROUND: Data regarding the prevalence of metallo-β-lactamases (MBLs) among Pseudomonas aeruginosa isolates in cystic fibrosis patients are scarce. Furthermore, there is limited knowledge on the effect of MBL production on patient outcomes. Here we describe a fatal respiratory infection due to P. aeruginosa producing VIM-type MBLs in a lung transplant recipient and the results of the subsequent epidemiological investigation. CASE PRESENTATION: P. aeruginosa isolates collected in the index patient and among patients temporally or spatially linked with the index patient were analyzed in terms of antibiotic susceptibility profile and MBL production. Whole-genome sequencing and phylogenetic reconstruction were also performed for all P. aeruginosa isolates producing VIM-type MBLs. A VIM-producing P. aeruginosa strain was identified in a lung biopsy of a lung transplant recipient with cystic fibrosis. The strain was VIM-1-producer and belonged to the ST308. Despite aggressive treatment, the transplant patient succumbed to the pulmonary infection due to the ST308 strain. A VIM-producing P. aeruginosa strain was also collected from the respiratory samples of a different cystic fibrosis patient attending the same cystic fibrosis center. This isolate harbored the blaVIM-2 gene and belonged to the clone ST175. This patient did not experience an adverse outcome. CONCLUSIONS: This is the first description of a fatal infection due to P. aeruginosa producing VIM-type MBLs in a lung transplant recipient. The circulation of P. aeruginosa isolates harboring MBLs pose a substantial risk to the cystic fibrosis population due to the limited therapeutic options available and their spreading potential.

Full Text

Duke Authors

Cited Authors

  • Carugati, M; Piazza, A; Peri, AM; Cariani, L; Brilli, M; Girelli, D; Di Carlo, D; Gramegna, A; Pappalettera, M; Comandatore, F; Grasselli, G; Cantù, AP; Arghittu, M; Gori, A; Bandi, C; Blasi, F; Bandera, A; IFALT working group,

Published Date

  • August 26, 2020

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 635 -

PubMed ID

  • 32847524

Pubmed Central ID

  • 32847524

Electronic International Standard Serial Number (EISSN)

  • 1471-2334

Digital Object Identifier (DOI)

  • 10.1186/s12879-020-05338-3

Language

  • eng

Conference Location

  • England