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Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity

Publication ,  Journal Article
Beckford, FA; Stott, A; Gonzalez‐Sarrías, A; Seeram, NP
Published in: Applied Organometallic Chemistry
July 2013

We have used a novel microwave‐assisted method to synthesize a pair of half‐sandwich ruthenium–arene–thiosemicarbazone complexes of the type [(η‐CHRu(TSC)Cl]PF. The thiosemicarbazone (TSC) ligands are 2‐(anthracen‐9‐ylmethylene)hydrazinecarbothioamide and 2‐(anthracen‐9‐ylmethylene)‐‐ethylhydrazinecarbothioamide derived from 9‐anthraldehyde. The complexes are moderately strong binders of DNA, with binding constants of 10. They are also strong binders of human serum albumin, having binding constants of the order of 10. The complexes show some in anticancer activity against human colon cancer cells, Caco‐2 and HCT‐116, with positive therapeutic indices. They did not show any activity as antibacterial agents against the organisms that were studied. Copyright © 2013 John Wiley & Sons, Ltd.

Duke Scholars

Published In

Applied Organometallic Chemistry

DOI

EISSN

1099-0739

ISSN

0268-2605

Publication Date

July 2013

Volume

27

Issue

7

Start / End Page

425 / 434

Publisher

Wiley

Related Subject Headings

  • Inorganic & Nuclear Chemistry
  • 3405 Organic chemistry
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0305 Organic Chemistry
  • 0302 Inorganic Chemistry
 

Citation

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Beckford, F. A., Stott, A., Gonzalez‐Sarrías, A., & Seeram, N. P. (2013). Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity. Applied Organometallic Chemistry, 27(7), 425–434. https://doi.org/10.1002/aoc.3007
Beckford, Floyd A., Alyssa Stott, Antonio Gonzalez‐Sarrías, and Navindra P. Seeram. “Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity.” Applied Organometallic Chemistry 27, no. 7 (July 2013): 425–34. https://doi.org/10.1002/aoc.3007.
Beckford FA, Stott A, Gonzalez‐Sarrías A, Seeram NP. Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity. Applied Organometallic Chemistry. 2013 Jul;27(7):425–34.
Beckford, Floyd A., et al. “Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity.” Applied Organometallic Chemistry, vol. 27, no. 7, Wiley, July 2013, pp. 425–34. Crossref, doi:10.1002/aoc.3007.
Beckford FA, Stott A, Gonzalez‐Sarrías A, Seeram NP. Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity. Applied Organometallic Chemistry. Wiley; 2013 Jul;27(7):425–434.
Journal cover image

Published In

Applied Organometallic Chemistry

DOI

EISSN

1099-0739

ISSN

0268-2605

Publication Date

July 2013

Volume

27

Issue

7

Start / End Page

425 / 434

Publisher

Wiley

Related Subject Headings

  • Inorganic & Nuclear Chemistry
  • 3405 Organic chemistry
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
  • 0305 Organic Chemistry
  • 0302 Inorganic Chemistry