Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

Journal Article (Journal Article)

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton's tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS.

Full Text

Duke Authors

Cited Authors

  • Gudjonsson, JE; Tsoi, LC; Ma, F; Billi, AC; van Straalen, KR; Vossen, ARJV; van der Zee, HH; Harms, PW; Wasikowski, R; Yee, CM; Rizvi, SM; Xing, X; Xing, E; Plazyo, O; Zeng, C; Patrick, MT; Lowe, MM; Burney, RE; Kozlow, JH; Cherry-Bukowiec, JR; Jiang, Y; Kirma, J; Weidinger, S; Cushing, KC; Rosenblum, MD; Berthier, C; MacLeod, AS; Voorhees, JJ; Wen, F; Kahlenberg, JM; Maverakis, E; Modlin, RL; Prens, EP

Published Date

  • October 2, 2020

Published In

Volume / Issue

  • 5 / 19

PubMed ID

  • 32853177

Pubmed Central ID

  • PMC7566715

Electronic International Standard Serial Number (EISSN)

  • 2379-3708

Digital Object Identifier (DOI)

  • 10.1172/jci.insight.139930

Language

  • eng

Conference Location

  • United States