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Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

Publication ,  Journal Article
Gudjonsson, JE; Tsoi, LC; Ma, F; Billi, AC; van Straalen, KR; Vossen, ARJV; van der Zee, HH; Harms, PW; Wasikowski, R; Yee, CM; Rizvi, SM ...
Published in: JCI Insight
October 2, 2020

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton's tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS.

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Published In

JCI Insight

DOI

EISSN

2379-3708

Publication Date

October 2, 2020

Volume

5

Issue

19

Location

United States

Related Subject Headings

  • Transcriptome
  • Syk Kinase
  • Single-Cell Analysis
  • Signal Transduction
  • Proteome
  • Plasma Cells
  • Humans
  • Hidradenitis Suppurativa
  • Gene Regulatory Networks
  • Gene Expression Regulation
 

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Gudjonsson, J. E., Tsoi, L. C., Ma, F., Billi, A. C., van Straalen, K. R., Vossen, A. R. J. V., … Prens, E. P. (2020). Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight, 5(19). https://doi.org/10.1172/jci.insight.139930
Gudjonsson, Johann E., Lam C. Tsoi, Feiyang Ma, Allison C. Billi, K. R. van Straalen, A. R. J. V. Vossen, H. H. van der Zee, et al. “Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.JCI Insight 5, no. 19 (October 2, 2020). https://doi.org/10.1172/jci.insight.139930.
Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen ARJV, et al. Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight. 2020 Oct 2;5(19).
Gudjonsson, Johann E., et al. “Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.JCI Insight, vol. 5, no. 19, Oct. 2020. Pubmed, doi:10.1172/jci.insight.139930.
Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen ARJV, van der Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow JH, Cherry-Bukowiec JR, Jiang Y, Kirma J, Weidinger S, Cushing KC, Rosenblum MD, Berthier C, MacLeod AS, Voorhees JJ, Wen F, Kahlenberg JM, Maverakis E, Modlin RL, Prens EP. Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight. 2020 Oct 2;5(19).

Published In

JCI Insight

DOI

EISSN

2379-3708

Publication Date

October 2, 2020

Volume

5

Issue

19

Location

United States

Related Subject Headings

  • Transcriptome
  • Syk Kinase
  • Single-Cell Analysis
  • Signal Transduction
  • Proteome
  • Plasma Cells
  • Humans
  • Hidradenitis Suppurativa
  • Gene Regulatory Networks
  • Gene Expression Regulation