Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton's tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS.
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Related Subject Headings
- Transcriptome
- Syk Kinase
- Single-Cell Analysis
- Signal Transduction
- Proteome
- Plasma Cells
- Humans
- Hidradenitis Suppurativa
- Gene Regulatory Networks
- Gene Expression Regulation
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Location
Related Subject Headings
- Transcriptome
- Syk Kinase
- Single-Cell Analysis
- Signal Transduction
- Proteome
- Plasma Cells
- Humans
- Hidradenitis Suppurativa
- Gene Regulatory Networks
- Gene Expression Regulation