© 2020, Associacao Iberica de Sistemas e Tecnologias de Informacao. All rights reserved. For an immersive Virtual Reality (IVR) application to be more effective, the user needs to feel “present” in it. It is recurrent, though, that the user has an impaired sense of presence. In many cases, this variation can be explained by the Uncanny Valley (UV) theory. In this context, this paper presents a systematic literature review that summarizes the results of studies about the occurrence of UV caused by the user’s virtual hands in IVR applications. Users have the expectation of trying to predict how appearances, motions, textures, and interactions would look like in real life. Thus, in situations in which, during the application, an elementimperfectly resembles the real, the UV occurs, generating eeriness in the user and reducing their sense of presence and immersion. A user-centered design process must deal with user frustration and, therefore, identify and mitigate possible UV threats.