Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics

Journal Article (Review;Journal)

Genetic studies have identified variants in the LRRK2 gene as important components of Parkinson’s disease (PD) pathobiology. Biochemical and emergent biomarker studies have coalesced around LRRK2 hyperactivation in disease. Therapeutics that diminish LRRK2 activity, either with small molecule kinase inhibitors or anti-sense oligonucleotides, have recently advanced to the clinic. Historically, there have been few successes in the development of therapies that might slow or halt the progression of neurodegenerative diseases. Over the past few decades of biomedical research, retrospective analyses suggest the broad integration of informative biomarkers early in development tends to distinguish successful pipelines from those that fail early. Herein, we discuss the biomarker regulatory process, emerging LRRK2 biomarker candidates, assays, underlying biomarker biology, and clinical integration.

Full Text

Duke Authors

Cited Authors

  • Kelly, K; West, AB

Published Date

  • August 6, 2020

Published In

Volume / Issue

  • 14 /

Electronic International Standard Serial Number (EISSN)

  • 1662-453X

International Standard Serial Number (ISSN)

  • 1662-4548

Digital Object Identifier (DOI)

  • 10.3389/fnins.2020.00807

Citation Source

  • Scopus