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Apheresis to Mitigate Atherosclerotic Vascular Disease.

Publication ,  Conference
Sachais, BS; Shaz, BH
Published in: Am J Hypertens
July 16, 2018

BACKGROUND: Therapeutic apheresis is a term used to describe a group of treatments where blood components are separated in real time, and one component is removed, exchanged, and/or treated to remove pathogenic substances from the circulation. Plasma exchange, which removed all plasma components, and lipid apheresis which selectively removes lipoproteins from circulation, have both been used to treat atherosclerotic vascular diseases. METHODS: To review the literature regarding the application of therapeutic apheresis for atherosclerotic vascular diseases. RESULTS: Primarily lipid apheresis is used to treat atherosclerotic vascular diseases, particularly familial hypercholesterolemia, lipoprotein (a) hyperlipoproteinemia and peripheral vascular diseases. Lipid apheresis can be used as first line or second line treatment with a strong evidenced-based recommendation. Its use has decreased atherosclerotic events. CONCLUSION: Lipid apheresis is an important therapy for the treatment of familial hypercholesterolemia, lipoprotein (a) hyperlipoproteinemia and peripheral vascular diseases. Lipid apheresis does more than remove low-density lipoproteins and other lipoproteins but also decreases inflammatory markers and improves blood flow.

Duke Scholars

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

July 16, 2018

Volume

31

Issue

8

Start / End Page

945 / 949

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Peripheral Arterial Disease
  • Lipoprotein(a)
  • Lipids
  • Hyperlipoproteinemias
  • Hyperlipoproteinemia Type II
  • Humans
  • Cholesterol, LDL
  • Cardiovascular System & Hematology
 

Citation

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Sachais, B. S., & Shaz, B. H. (2018). Apheresis to Mitigate Atherosclerotic Vascular Disease. In Am J Hypertens (Vol. 31, pp. 945–949). United States. https://doi.org/10.1093/ajh/hpy068
Sachais, Bruce S., and Beth H. Shaz. “Apheresis to Mitigate Atherosclerotic Vascular Disease.” In Am J Hypertens, 31:945–49, 2018. https://doi.org/10.1093/ajh/hpy068.
Sachais BS, Shaz BH. Apheresis to Mitigate Atherosclerotic Vascular Disease. In: Am J Hypertens. 2018. p. 945–9.
Sachais, Bruce S., and Beth H. Shaz. “Apheresis to Mitigate Atherosclerotic Vascular Disease.Am J Hypertens, vol. 31, no. 8, 2018, pp. 945–49. Pubmed, doi:10.1093/ajh/hpy068.
Sachais BS, Shaz BH. Apheresis to Mitigate Atherosclerotic Vascular Disease. Am J Hypertens. 2018. p. 945–949.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

July 16, 2018

Volume

31

Issue

8

Start / End Page

945 / 949

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Peripheral Arterial Disease
  • Lipoprotein(a)
  • Lipids
  • Hyperlipoproteinemias
  • Hyperlipoproteinemia Type II
  • Humans
  • Cholesterol, LDL
  • Cardiovascular System & Hematology