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Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART

Publication ,  Journal Article
Cade, WT; Reeds, DN; Mittendorfer, B; Patterson, BW; Powderly, WG; Klein, S; Yarasheski, KE
Published in: American Journal of Physiology-Endocrinology and Metabolism
March 2007

The protease inhibitor (PI) ritonavir (RTV) has been associated with elevated resting lipolytic rate, hyperlipidemia, and insulin resistance/glucose intolerance. The purpose of this study was to examine relationships between lipolysis and fatty acid (FA) oxidation during rest, moderate exercise and recovery, and measures of insulin sensitivity/glucose tolerance and fat redistribution in HIV-positive subjects taking RTV ( n = 12), HAART but no PI ( n = 10), and HIV-seronegative controls ( n = 10). Stable isotope tracers [1-C]palmitate and [1,1,2,3,3-H]glycerol were continuously infused with blood and breath collection during 1-h rest, 70-min submaximal exercise (50% V̇o), and 1-h recovery. Body composition was evaluated using DEXA, MRI, and MRS, and 2-h oral glucose tolerance tests with insulin monitoring were used to evaluate glucose tolerance and insulin resistance. Lipolytic and FA oxidation rates were similar during rest and recovery in all groups; however, they were lower during moderate exercise in both HIV-infected groups [glycerol R: HIV + RTV 5.1 ± 1.2 vs. HIV + no PI 5.9 ± 2.8 vs. Control 7.4 ± 2.2 μmol·kg fat-free mass (FFM)·min; palmitate oxidation: HIV + RTV 1.6 ± 0.8 vs. HIV + no PI 1.6 ± 0.8 vs. Control 2.5 ± 1.7 μmol·kg FFM·min, P < 0.01]. Fasting and orally-challenged glucose and insulin values were similar among groups. Lipolytic and FA oxidation rates were blunted during moderate exercise in HIV-positive subjects taking HAART. Lower FA oxidation during exercise was primarily due to impaired plasma FA oxidation, with a minor contribution from lower nonplasma FA oxidation. Regional differences in adipose tissue lipolysis during rest and moderate exercise may be important in HIV and warrant further study.

Duke Scholars

Published In

American Journal of Physiology-Endocrinology and Metabolism

DOI

EISSN

1522-1555

ISSN

0193-1849

Publication Date

March 2007

Volume

292

Issue

3

Start / End Page

E812 / E819

Publisher

American Physiological Society

Related Subject Headings

  • Endocrinology & Metabolism
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Cade, W. T., Reeds, D. N., Mittendorfer, B., Patterson, B. W., Powderly, W. G., Klein, S., & Yarasheski, K. E. (2007). Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART. American Journal of Physiology-Endocrinology and Metabolism, 292(3), E812–E819. https://doi.org/10.1152/ajpendo.00300.2006
Cade, W Todd, Dominic N. Reeds, Bettina Mittendorfer, Bruce W. Patterson, William G. Powderly, Samuel Klein, and Kevin E. Yarasheski. “Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART.” American Journal of Physiology-Endocrinology and Metabolism 292, no. 3 (March 2007): E812–19. https://doi.org/10.1152/ajpendo.00300.2006.
Cade WT, Reeds DN, Mittendorfer B, Patterson BW, Powderly WG, Klein S, et al. Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART. American Journal of Physiology-Endocrinology and Metabolism. 2007 Mar;292(3):E812–9.
Cade, W. Todd, et al. “Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART.” American Journal of Physiology-Endocrinology and Metabolism, vol. 292, no. 3, American Physiological Society, Mar. 2007, pp. E812–19. Crossref, doi:10.1152/ajpendo.00300.2006.
Cade WT, Reeds DN, Mittendorfer B, Patterson BW, Powderly WG, Klein S, Yarasheski KE. Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART. American Journal of Physiology-Endocrinology and Metabolism. American Physiological Society; 2007 Mar;292(3):E812–E819.

Published In

American Journal of Physiology-Endocrinology and Metabolism

DOI

EISSN

1522-1555

ISSN

0193-1849

Publication Date

March 2007

Volume

292

Issue

3

Start / End Page

E812 / E819

Publisher

American Physiological Society

Related Subject Headings

  • Endocrinology & Metabolism
  • 11 Medical and Health Sciences
  • 06 Biological Sciences