Mechanisms of NOD-like receptor-associated inflammasome activation.

Journal Article (Review;Journal Article)

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.

Full Text

Duke Authors

Cited Authors

  • Wen, H; Miao, EA; Ting, JP-Y

Published Date

  • September 2013

Published In

Volume / Issue

  • 39 / 3

Start / End Page

  • 432 - 441

PubMed ID

  • 24054327

Pubmed Central ID

  • PMC3835203

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2013.08.037

Language

  • eng