NLRP1 - One NLR to guard them all.

Journal Article (Journal Article)

Microbial pathogens can be detected by inflammasomes that induce inflammation and programmed cell death. Inflammasomes are sensors that survey cells for signs of compromise. One of these sensors, NLRP1, detects anthrax lethal toxin; however, the mechanism of NLRP1 activation has remained unknown. Here, Xu et al discover NLRP1 cleavage by lethal toxin induces the N-end rule, which targets NLRP1 for degradation. Surprisingly, the active inflammasome fragment escapes the proteasome and becomes an activate inflammasome itself.

Full Text

Duke Authors

Cited Authors

  • Lacey, CA; Miao, EA

Published Date

  • July 2019

Published In

Volume / Issue

  • 38 / 13

Start / End Page

  • e102494 -

PubMed ID

  • 31268605

Pubmed Central ID

  • 31268605

Electronic International Standard Serial Number (EISSN)

  • 1460-2075

International Standard Serial Number (ISSN)

  • 0261-4189

Digital Object Identifier (DOI)

  • 10.15252/embj.2019102494

Language

  • eng