The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection.

Journal Article (Journal Article)

Inflammasomes are cytosolic protein complexes that regulate caspase-1 activation and the secretion of interleukin-1β (IL-1β) and IL-18. Several different inflammasome complexes have been identified, but the NLRP3 inflammasome is particularly notable because of its central role in diseases of inflammation. Recent work has demonstrated an essential role for the NLRP3 inflammasome in host defense against influenza virus. We show here that two other RNA viruses, encephalomyocarditis virus (EMCV) and vesicular stomatitis virus (VSV), activate the NLRP3 inflammasome in dendritic cells and macrophages through a mechanism requiring viral replication. Inflammasome activation in response to both viruses does not require MDA5 or RIG-I signaling. Despite the ability of the NLRP3 inflammasome to detect EMCV and VSV, wild-type and caspase-1-deficient mice were equally susceptible to infection with both viruses. These findings indicate that the NLRP3 inflammasome may be a common pathway for RNA virus detection, but its precise role in the host response may be variable.

Full Text

Duke Authors

Cited Authors

  • Rajan, JV; Rodriguez, D; Miao, EA; Aderem, A

Published Date

  • May 2011

Published In

Volume / Issue

  • 85 / 9

Start / End Page

  • 4167 - 4172

PubMed ID

  • 21289120

Pubmed Central ID

  • PMC3126243

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.01687-10

Language

  • eng