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Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.

Publication ,  Journal Article
Warren, SE; Armstrong, A; Hamilton, MK; Mao, DP; Leaf, IA; Miao, EA; Aderem, A
Published in: J Immunol
July 15, 2010

Pathogens are detected by pattern recognition receptors that, upon activation, orchestrate an appropriate immune response. The TLRs and the nucleotide-binding oligomerization domain-like receptors (NLRs) are prototypic pattern recognition receptors that detect extracellular and cytosolic pathogens, respectively. Listeria monocytogenes has both extracellular and cytosolic phases and is detected in the cytosol by members of the NLR family. These include two NLR members, NLRC4 and NLRP3, that, upon detection of cytosolic L. monocytogenes, induce the assembly of the inflammasome. Inflammasomes serve as platforms for the activation of the protease caspase 1, which mediates the processing and secretion of pro-IL-1beta and pro-IL-18. We previously provided evidence that L. monocytogenes is also detected by a third inflammasome. We now use biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA.

Duke Scholars

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

July 15, 2010

Volume

185

Issue

2

Start / End Page

818 / 821

Location

United States

Related Subject Headings

  • RNA Interference
  • Phagosomes
  • Nuclear Proteins
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Mice, Knockout
  • Mice
  • Macrophages
  • Listeria monocytogenes
  • L Cells
  • Interleukin-1beta
 

Citation

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MLA
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Warren, S. E., Armstrong, A., Hamilton, M. K., Mao, D. P., Leaf, I. A., Miao, E. A., & Aderem, A. (2010). Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol, 185(2), 818–821. https://doi.org/10.4049/jimmunol.1000724
Warren, Sarah E., Abraham Armstrong, M Kristina Hamilton, Dat P. Mao, Irina A. Leaf, Edward A. Miao, and Alan Aderem. “Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.J Immunol 185, no. 2 (July 15, 2010): 818–21. https://doi.org/10.4049/jimmunol.1000724.
Warren SE, Armstrong A, Hamilton MK, Mao DP, Leaf IA, Miao EA, et al. Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol. 2010 Jul 15;185(2):818–21.
Warren, Sarah E., et al. “Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.J Immunol, vol. 185, no. 2, July 2010, pp. 818–21. Pubmed, doi:10.4049/jimmunol.1000724.
Warren SE, Armstrong A, Hamilton MK, Mao DP, Leaf IA, Miao EA, Aderem A. Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol. 2010 Jul 15;185(2):818–821.

Published In

J Immunol

DOI

EISSN

1550-6606

Publication Date

July 15, 2010

Volume

185

Issue

2

Start / End Page

818 / 821

Location

United States

Related Subject Headings

  • RNA Interference
  • Phagosomes
  • Nuclear Proteins
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Mice, Knockout
  • Mice
  • Macrophages
  • Listeria monocytogenes
  • L Cells
  • Interleukin-1beta