Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.

Journal Article (Journal Article)

Pathogens are detected by pattern recognition receptors that, upon activation, orchestrate an appropriate immune response. The TLRs and the nucleotide-binding oligomerization domain-like receptors (NLRs) are prototypic pattern recognition receptors that detect extracellular and cytosolic pathogens, respectively. Listeria monocytogenes has both extracellular and cytosolic phases and is detected in the cytosol by members of the NLR family. These include two NLR members, NLRC4 and NLRP3, that, upon detection of cytosolic L. monocytogenes, induce the assembly of the inflammasome. Inflammasomes serve as platforms for the activation of the protease caspase 1, which mediates the processing and secretion of pro-IL-1beta and pro-IL-18. We previously provided evidence that L. monocytogenes is also detected by a third inflammasome. We now use biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA.

Full Text

Duke Authors

Cited Authors

  • Warren, SE; Armstrong, A; Hamilton, MK; Mao, DP; Leaf, IA; Miao, EA; Aderem, A

Published Date

  • July 2010

Published In

Volume / Issue

  • 185 / 2

Start / End Page

  • 818 - 821

PubMed ID

  • 20562263

Pubmed Central ID

  • 20562263

Electronic International Standard Serial Number (EISSN)

  • 1550-6606

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.1000724

Language

  • eng