Multimodal handheld adaptive optics scanning laser ophthalmoscope.

Journal Article (Journal Article)

Non-confocal adaptive optics scanning laser ophthalmoscopy (AOSLO) has enhanced the study of human retinal photoreceptors by providing complementary information to standard confocal AOSLO images. Previously we developed the first confocal handheld AOSLO (HAOSLO) capable of in vivo cone photoreceptor imaging in supine and non-cooperative patients. Here, we introduce the first multimodal (M-)HAOSLO for confocal and non-confocal split-detection (SD) imaging to allow for more comprehensive patient data collection. Aside from its unprecedented miniature size and weight, M-HAOSLO is also the first system to perform sensorless wavefront-corrected SD imaging of cone photoreceptors.

Full Text

Duke Authors

Cited Authors

  • Hagan, K; DuBose, T; Cunefare, D; Waterman, G; Park, J; Simmerer, C; Kuo, AN; McNabb, RP; Izatt, JA; Farsiu, S

Published Date

  • September 1, 2020

Published In

Volume / Issue

  • 45 / 17

Start / End Page

  • 4940 - 4943

PubMed ID

  • 32870897

Pubmed Central ID

  • PMC7792463

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

Digital Object Identifier (DOI)

  • 10.1364/OL.402392


  • eng

Conference Location

  • United States