The evolving metabolic landscape of chromatin biology and epigenetics.

Journal Article (Journal Article;Review)

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs - which include both nutrient availability as a result of diet and growth factor signalling - are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.

Full Text

Duke Authors

Cited Authors

  • Dai, Z; Ramesh, V; Locasale, JW

Published Date

  • December 2020

Published In

Volume / Issue

  • 21 / 12

Start / End Page

  • 737 - 753

PubMed ID

  • 32908249

Pubmed Central ID

  • 32908249

Electronic International Standard Serial Number (EISSN)

  • 1471-0064

Digital Object Identifier (DOI)

  • 10.1038/s41576-020-0270-8

Language

  • eng

Conference Location

  • England