The evolving metabolic landscape of chromatin biology and epigenetics.
Journal Article (Journal Article;Review)
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs - which include both nutrient availability as a result of diet and growth factor signalling - are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.
Full Text
Duke Authors
Cited Authors
- Dai, Z; Ramesh, V; Locasale, JW
Published Date
- December 2020
Published In
Volume / Issue
- 21 / 12
Start / End Page
- 737 - 753
PubMed ID
- 32908249
Pubmed Central ID
- PMC8059378
Electronic International Standard Serial Number (EISSN)
- 1471-0064
Digital Object Identifier (DOI)
- 10.1038/s41576-020-0270-8
Language
- eng
Conference Location
- England