Influence of structural and functional brain connectivity on age-related differences in fluid cognition.

Journal Article (Journal Article)

We used graph theoretical measures to investigate the hypothesis that structural brain connectivity constrains the influence of functional connectivity on the relation between age and fluid cognition. Across 143 healthy, community-dwelling adults 19-79 years of age, we estimated structural network properties from diffusion-weighted imaging and functional network properties from resting-state functional magnetic resonance imaging. We confirmed previous reports of age-related decline in the strength and efficiency of structural networks, as well as in the connectivity strength within and between structural network modules. Functional networks, in contrast, exhibited age-related decline only in system segregation, a measure of the distinctiveness among network modules. Aging was associated with decline in a composite measure of fluid cognition, particularly tests of executive function. Functional system segregation was a significant mediator of age-related decline in executive function. Structural network properties did not directly influence the age-related decline in functional system segregation. The raw correlational data underlying the graph theoretical measures indicated that structural connectivity exerts a limited constraint on age-related decline in functional connectivity.

Full Text

Duke Authors

Cited Authors

  • Madden, DJ; Jain, S; Monge, ZA; Cook, AD; Lee, A; Huang, H; Howard, CM; Cohen, JR

Published Date

  • December 2020

Published In

Volume / Issue

  • 96 /

Start / End Page

  • 205 - 222

PubMed ID

  • 33038808

Pubmed Central ID

  • PMC7722190

Electronic International Standard Serial Number (EISSN)

  • 1558-1497

Digital Object Identifier (DOI)

  • 10.1016/j.neurobiolaging.2020.09.010


  • eng

Conference Location

  • United States