Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.
Cottrell, CA; van Schooten, J; Bowman, CA; Yuan, M; Oyen, D; Shin, M; Morpurgo, R; van der Woude, P; van Breemen, M; Torres, JL; Patel, R; Gross, J; Sewall, LM; Copps, J; Ozorowski, G; Nogal, B; Sok, D; Rakasz, EG; Labranche, C; Vigdorovich, V; Christley, S; Carnathan, DG; Sather, DN; Montefiori, D; Silvestri, G; Burton, DR; Moore, JP; Wilson, IA; Sanders, RW; Ward, AB; van Gils, MJ
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