Counting on natural products for drug design.

Published

Journal Article (Review)

Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.

Full Text

Duke Authors

Cited Authors

  • Rodrigues, T; Reker, D; Schneider, P; Schneider, G

Published Date

  • June 2016

Published In

Volume / Issue

  • 8 / 6

Start / End Page

  • 531 - 541

PubMed ID

  • 27219696

Pubmed Central ID

  • 27219696

Electronic International Standard Serial Number (EISSN)

  • 1755-4349

International Standard Serial Number (ISSN)

  • 1755-4330

Digital Object Identifier (DOI)

  • 10.1038/nchem.2479

Language

  • eng