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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.

Publication ,  Journal Article
International Multiple Sclerosis Genetics Consortium,
Published in: Science
September 27, 2019

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.

Duke Scholars

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

September 27, 2019

Volume

365

Issue

6460

Location

United States

Related Subject Headings

  • Transcriptome
  • RNA-Seq
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Multiple Sclerosis
  • Microglia
  • Major Histocompatibility Complex
  • Inheritance Patterns
  • Humans
  • Genomics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
International Multiple Sclerosis Genetics Consortium, . (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science, 365(6460). https://doi.org/10.1126/science.aav7188
International Multiple Sclerosis Genetics Consortium, Stanley M. “Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.Science 365, no. 6460 (September 27, 2019). https://doi.org/10.1126/science.aav7188.
International Multiple Sclerosis Genetics Consortium. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019 Sep 27;365(6460).
International Multiple Sclerosis Genetics Consortium, Stanley M. “Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.Science, vol. 365, no. 6460, Sept. 2019. Pubmed, doi:10.1126/science.aav7188.
International Multiple Sclerosis Genetics Consortium. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. 2019 Sep 27;365(6460).
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

September 27, 2019

Volume

365

Issue

6460

Location

United States

Related Subject Headings

  • Transcriptome
  • RNA-Seq
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Multiple Sclerosis
  • Microglia
  • Major Histocompatibility Complex
  • Inheritance Patterns
  • Humans
  • Genomics