Mitochondria in Ovarian Aging and Reproductive Longevity.

Journal Article (Journal Article;Review)

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA (mtDNA) copy number and function decline with age in various tissues. There is increasing evidence to support that mitochondrial dysfunction drives ovarian aging. A decreased mtDNA copy number is also reported during ovarian aging. However, the mitochondrial mechanisms contributing to ovarian aging and infertility are not fully understood. Additionally, investigations into mitochondrial therapies to rejuvenate oocyte quality, select viable embryos and improve mitochondrial function may help enhance fertility or extend reproductive longevity in the future. These therapies include the use of mitochondrial replacement techniques, quantification of mtDNA copy number, and various pharmacologic and lifestyle measures. This review aims to describe the key evidence and current knowledge of the role of mitochondria in ovarian aging and identify the emerging potential options for therapy to extend reproductive longevity and improve fertility.

Full Text

Duke Authors

Cited Authors

  • Chiang, JL; Shukla, P; Pagidas, K; Ahmed, NS; Karri, S; Gunn, DD; Hurd, WW; Singh, KK

Published Date

  • November 2020

Published In

Volume / Issue

  • 63 /

Start / End Page

  • 101168 -

PubMed ID

  • 32896666

Electronic International Standard Serial Number (EISSN)

  • 1872-9649

Digital Object Identifier (DOI)

  • 10.1016/j.arr.2020.101168

Language

  • eng

Conference Location

  • England