Ignoring correlated activity causes a failure of retinal population codes.

Published online

Journal Article

From starlight to sunlight, adaptation alters retinal output, changing both the signal and noise among populations of retinal ganglion cells (RGCs). Here we determine how these light level-dependent changes impact decoding of retinal output, testing the importance of accounting for RGC noise correlations to optimally read out retinal activity. We find that at moonlight conditions, correlated noise is greater and assuming independent noise severely diminishes decoding performance. In fact, assuming independence among a local population of RGCs produces worse decoding than using a single RGC, demonstrating a failure of population codes when correlated noise is substantial and ignored. We generalize these results with a simple model to determine what conditions dictate this failure of population processing. This work elucidates the circumstances in which accounting for noise correlations is necessary to take advantage of population-level codes and shows that sensory adaptation can strongly impact decoding requirements on downstream brain areas.

Full Text

Duke Authors

Cited Authors

  • Ruda, K; Zylberberg, J; Field, GD

Published Date

  • September 14, 2020

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 4605 -

PubMed ID

  • 32929073

Pubmed Central ID

  • 32929073

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-020-18436-2

Language

  • eng

Conference Location

  • England