High-Strength Hydrogel Attachment through Nanofibrous Reinforcement.

Published

Journal Article

The repair of a cartilage lesion with a hydrogel requires a method for long-term fixation of the hydrogel in the defect site. Attachment of a hydrogel to a base that allows for integration with bone can enable long-term fixation of the hydrogel, but current methods of forming bonds to hydrogels have less than a tenth of the shear strength of the osteochondral junction. This communication describes a new method, nanofiber-enhanced sticking (NEST), for bonding a hydrogel to a base with an adhesive shear strength three times larger than the state-of-the-art. An example of NEST is described in which a nanofibrous bacterial cellulose sheet is bonded to a porous base with a hydroxyapatite-forming cement followed by infiltration of the nanofibrous sheet with hydrogel-forming polymeric materials. This approach creates a mineralized nanofiber bond that mimics the structure of the osteochondral junction, in which collagen nanofibers extend from cartilage into a mineralized region that anchors cartilage to bone.

Full Text

Duke Authors

Cited Authors

  • Zhao, J; Kirillova, A; Kelly, CN; Xu, H; Koshut, WJ; Yang, F; Gall, K; Wiley, BJ

Published Date

  • September 16, 2020

Published In

Start / End Page

  • e2001119 -

PubMed ID

  • 32940005

Pubmed Central ID

  • 32940005

Electronic International Standard Serial Number (EISSN)

  • 2192-2659

International Standard Serial Number (ISSN)

  • 2192-2640

Digital Object Identifier (DOI)

  • 10.1002/adhm.202001119

Language

  • eng