Obesity-related asthma in children: A role for vitamin D.

Journal Article (Review;Journal Article)

Excess adipose tissue predisposes to an enhanced inflammatory state and can contribute to the pathogenesis and severity of asthma. Vitamin D has anti-inflammatory properties and low-serum levels are seen in children with asthma and in children with obesity. Here we review the intersection of asthma, obesity, and hypovitaminosis D in children. Supplementation with vitamin D has been proposed as a simple, safe, and inexpensive adjunctive therapy in a number of disease states. However, little research has examined the pharmacokinetics of vitamin D and its therapeutic potential in children who suffer from obesity-related asthma.

Full Text

Duke Authors

Cited Authors

  • O'Sullivan, BP; James, L; Majure, JM; Bickel, S; Phan, L-T; Serrano Gonzalez, M; Staples, H; Tam-Williams, J; Lang, J; Snowden, J; IDeA States Pediatric Clinical Trials Network,

Published Date

  • February 2021

Published In

Volume / Issue

  • 56 / 2

Start / End Page

  • 354 - 361

PubMed ID

  • 32930511

Pubmed Central ID

  • PMC8341445

Electronic International Standard Serial Number (EISSN)

  • 1099-0496

International Standard Serial Number (ISSN)

  • 8755-6863

Digital Object Identifier (DOI)

  • 10.1002/ppul.25053

Language

  • eng