Obesity-related asthma in children: A role for vitamin D.
Excess adipose tissue predisposes to an enhanced inflammatory state and can contribute to the pathogenesis and severity of asthma. Vitamin D has anti-inflammatory properties and low-serum levels are seen in children with asthma and in children with obesity. Here we review the intersection of asthma, obesity, and hypovitaminosis D in children. Supplementation with vitamin D has been proposed as a simple, safe, and inexpensive adjunctive therapy in a number of disease states. However, little research has examined the pharmacokinetics of vitamin D and its therapeutic potential in children who suffer from obesity-related asthma.
O'Sullivan, BP; James, L; Majure, JM; Bickel, S; Phan, L-T; Serrano Gonzalez, M; Staples, H; Tam-Williams, J; Lang, J; Snowden, J; IDeA States Pediatric Clinical Trials Network,
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