Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review.

Journal Article (Journal Article;Review)

Neurodegenerative disorders are characterized by mitochondrial dysfunction and subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal cytotoxicity and degeneration. Recent studies reported that crocin, a carotenoid chemical compound common in crocus and gardenia flowers, has protective effects in neurodegenerative disorders due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties in the nervous system. This article reviews the new experimental, clinical, and pharmacological studies on the neuroprotective properties of crocin and its potential mechanisms to modulate metabolic oxidative stress and inflammation in neurodegenerative disorders.

Full Text

Duke Authors

Cited Authors

  • Kermanshahi, S; Ghanavati, G; Abbasi-Mesrabadi, M; Gholami, M; Ulloa, L; Motaghinejad, M; Safari, S

Published Date

  • November 2020

Published In

Volume / Issue

  • 45 / 11

Start / End Page

  • 2573 - 2585

PubMed ID

  • 32940861

Electronic International Standard Serial Number (EISSN)

  • 1573-6903

Digital Object Identifier (DOI)

  • 10.1007/s11064-020-03134-8


  • eng

Conference Location

  • United States