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Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function.

Publication ,  Journal Article
Sui, J; Li, X; Bell, RP; Towe, SL; Gadde, S; Chen, N-K; Meade, CS
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
October 2021

Human immunodeficiency virus (HIV)-associated neurocognitive impairment remains a prevalent comorbidity that impacts daily functioning and increases morbidity. While HIV infection is known to cause widespread disruptions in the brain, different magnetic resonance imaging (MRI) modalities have not been effectively integrated. In this study, we applied 3-way supervised fusion to investigate how structural and functional coalterations affect cognitive function.Participants (59 people living with HIV and 58 without HIV) completed comprehensive neuropsychological testing and multimodal MRI scanning to acquire high-resolution anatomical, diffusion-weighted, and resting-state functional images. Preprocessed data were reduced using voxel-based morphometry, probabilistic tractography, and regional homogeneity, respectively. We applied multimodal canonical correlation analysis with reference plus joint independent component analysis using global cognitive functioning as the reference.Compared with controls, participants living with HIV had lower global cognitive functioning. One joint component was both group discriminating and correlated with cognitive function. This component included the following covarying regions: fractional anisotropy in the corpus callosum, short and long association fiber tracts, and corticopontine fibers; gray matter volume in the thalamus, prefrontal cortex, precuneus, posterior parietal regions, and occipital lobe; and functional connectivity in frontoparietal and visual processing regions. Component loadings for fractional anisotropy also correlated with immunosuppression.These results suggest that coalterations in brain structure and function can distinguish people with and without HIV and may drive cognitive impairment. As MRI becomes more commonplace in HIV care, multimodal fusion may provide neural biomarkers to support diagnosis and treatment of cognitive impairment.

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Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

October 2021

Volume

73

Issue

7

Start / End Page

e2287 / e2293

Related Subject Headings

  • White Matter
  • Microbiology
  • Magnetic Resonance Imaging
  • Humans
  • HIV Infections
  • HIV
  • Cognition
  • Brain
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Sui, J., Li, X., Bell, R. P., Towe, S. L., Gadde, S., Chen, N.-K., & Meade, C. S. (2021). Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 73(7), e2287–e2293. https://doi.org/10.1093/cid/ciaa1415
Sui, Jing, Xiang Li, Ryan P. Bell, Sheri L. Towe, Syam Gadde, Nan-Kuei Chen, and Christina S. Meade. “Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 73, no. 7 (October 2021): e2287–93. https://doi.org/10.1093/cid/ciaa1415.
Sui J, Li X, Bell RP, Towe SL, Gadde S, Chen N-K, et al. Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Oct;73(7):e2287–93.
Sui, Jing, et al. “Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function.Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, vol. 73, no. 7, Oct. 2021, pp. e2287–93. Epmc, doi:10.1093/cid/ciaa1415.
Sui J, Li X, Bell RP, Towe SL, Gadde S, Chen N-K, Meade CS. Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Oct;73(7):e2287–e2293.
Journal cover image

Published In

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

DOI

EISSN

1537-6591

ISSN

1058-4838

Publication Date

October 2021

Volume

73

Issue

7

Start / End Page

e2287 / e2293

Related Subject Headings

  • White Matter
  • Microbiology
  • Magnetic Resonance Imaging
  • Humans
  • HIV Infections
  • HIV
  • Cognition
  • Brain
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences