Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.

Journal Article (Journal Article)

Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on aging and longevity biomarkers in humans. Building on CALERIE phase 1, CALERIE phase 2 (CALERIE 2) was the largest study to date to assess sustained CR in healthy humans without obesity. In a 24-month randomized controlled trial comprising 218 participants at baseline, CALERIE 2 showed that moderate CR, 11.9% on average, induced improvements in aging-related biomarkers without adversely affecting psychological or behavioral outcomes. The objectives of this report are to summarize and review the highlights of CALERIE 2 and report previously unpublished results on eating disorder symptoms and cognitive function. This article specifically summarizes the physiological, psychological, aging, behavioral, and safety results of the trial. Also provided are research directions beyond CALERIE 2 that highlight important opportunities to investigate the role of CR in aging, longevity, and health span in humans.

Full Text

Duke Authors

Cited Authors

  • Dorling, JL; van Vliet, S; Huffman, KM; Kraus, WE; Bhapkar, M; Pieper, CF; Stewart, T; Das, SK; Racette, SB; Roberts, SB; Ravussin, E; Redman, LM; Martin, CK; CALERIE Study Group,

Published Date

  • January 1, 2021

Published In

Volume / Issue

  • 79 / 1

Start / End Page

  • 98 - 113

PubMed ID

  • 32940695

Pubmed Central ID

  • PMC7727025

Electronic International Standard Serial Number (EISSN)

  • 1753-4887

Digital Object Identifier (DOI)

  • 10.1093/nutrit/nuaa085


  • eng

Conference Location

  • United States