Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora .

Journal Article (Journal Article)

Five new [daphneodorins D-H (1 , 5 , and 10 -12 )] and seven known daphnane diterpenoids (2 -4 and 6 -9 ) were isolated from Daphne odora . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1 -9 ) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.

Full Text

Duke Authors

Cited Authors

  • Otsuki, K; Li, W; Miura, K; Asada, Y; Huang, L; Chen, C-H; Lee, K-H; Koike, K

Published Date

  • November 2020

Published In

Volume / Issue

  • 83 / 11

Start / End Page

  • 3270 - 3277

PubMed ID

  • 32997496

Pubmed Central ID

  • PMC8176625

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.0c00540

Language

  • eng