Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.
Journal Article (Journal Article)
Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.
Full Text
Duke Authors
Cited Authors
- Otsuki, K; Li, W; Miura, K; Asada, Y; Huang, L; Chen, C-H; Lee, K-H; Koike, K
Published Date
- November 25, 2020
Published In
Volume / Issue
- 83 / 11
Start / End Page
- 3270 - 3277
PubMed ID
- 32997496
Pubmed Central ID
- PMC8176625
Electronic International Standard Serial Number (EISSN)
- 1520-6025
Digital Object Identifier (DOI)
- 10.1021/acs.jnatprod.0c00540
Language
- eng
Conference Location
- United States