Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

Published

Journal Article

Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.

Full Text

Duke Authors

Cited Authors

  • Otsuki, K; Li, W; Miura, K; Asada, Y; Huang, L; Chen, C-H; Lee, K-H; Koike, K

Published Date

  • November 25, 2020

Published In

Volume / Issue

  • 83 / 11

Start / End Page

  • 3270 - 3277

PubMed ID

  • 32997496

Pubmed Central ID

  • 32997496

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.0c00540

Language

  • eng

Conference Location

  • United States