Skip to main content
Journal cover image

Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery.

Publication ,  Journal Article
Dickinson, SM; McIntyre, CA; Schilsky, JB; Harrington, KA; Gerst, SR; Flynn, JR; Gonen, M; Capanu, M; Wong, W; Lawrence, S; Allen, PJ; Do, RK ...
Published in: Abdom Radiol (NY)
April 2021

PURPOSE: To evaluate the associations between computed tomography (CT) imaging features extracted from the structured American Pancreatic Association (APA)/Society of Abdominal Radiology (SAR) template and overall survival in patients with resected pancreatic ductal adenocarcinoma (PDAC). METHODS: This retrospective analysis included consecutive patients with PDAC who consented to genomic tumor testing and underwent preoperative imaging and curative intent surgical resection from December 2006 to July 2017. Two radiologists assessed preoperative CT imaging using the APA/SAR PDAC-reporting template. Univariable associations between overall survival and imaging variables were evaluated using Cox proportional hazards regression. RESULTS: The study included 168 patients (66 years ± 11; 91 women). 126/168 patients (75%) received upfront surgical resection whereas 42/168 (25%) received neoadjuvant therapy prior to surgical resection. In the entire cohort, features associated with decreased overall survival were tumor arterial contact of any kind (hazard ratio (HR) 1.89, 95% CI 1.13-3.14, p = 0.020), tumor contact with the common hepatic artery (HR 2.33, 95% CI 1.35-4.04, p = 0.009), and portal vein deformity (HR 3.22, 95% CI 1.63-6.37, p = 0.003). In the upfront surgical group, larger tumor size was associated with decreased overall survival (HR 2.30, 95% CI 1.19-4.42, p = 0.013). In the neoadjuvant therapy group, the presence of venous collaterals was the only feature associated with decreased overall survival (HR 2.28, 95% CI 1.04-4.99, p = 0.042). CONCLUSION: The application of the APA/SAR pancreatic adenocarcinoma reporting template may identify predictors of survival that can aid in preoperative stratification of patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Abdom Radiol (NY)

DOI

EISSN

2366-0058

Publication Date

April 2021

Volume

46

Issue

4

Start / End Page

1607 / 1617

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Retrospective Studies
  • Prognosis
  • Pancreatic Neoplasms
  • Humans
  • Female
  • Carcinoma, Pancreatic Ductal
  • Adenocarcinoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dickinson, S. M., McIntyre, C. A., Schilsky, J. B., Harrington, K. A., Gerst, S. R., Flynn, J. R., … Do, R. K. (2021). Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery. Abdom Radiol (NY), 46(4), 1607–1617. https://doi.org/10.1007/s00261-020-02726-w
Dickinson, Shannan M., Caitlin A. McIntyre, Juliana B. Schilsky, Kate A. Harrington, Scott R. Gerst, Jessica R. Flynn, Mithat Gonen, et al. “Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery.Abdom Radiol (NY) 46, no. 4 (April 2021): 1607–17. https://doi.org/10.1007/s00261-020-02726-w.
Dickinson SM, McIntyre CA, Schilsky JB, Harrington KA, Gerst SR, Flynn JR, et al. Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery. Abdom Radiol (NY). 2021 Apr;46(4):1607–17.
Dickinson, Shannan M., et al. “Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery.Abdom Radiol (NY), vol. 46, no. 4, Apr. 2021, pp. 1607–17. Pubmed, doi:10.1007/s00261-020-02726-w.
Dickinson SM, McIntyre CA, Schilsky JB, Harrington KA, Gerst SR, Flynn JR, Gonen M, Capanu M, Wong W, Lawrence S, Allen PJ, O’Reilly EM, Jarnagin WR, D’Angelica MI, Balachandran VP, Drebin JA, Kingham TP, Simpson AL, Do RK. Preoperative CT predictors of survival in patients with pancreatic ductal adenocarcinoma undergoing curative intent surgery. Abdom Radiol (NY). 2021 Apr;46(4):1607–1617.
Journal cover image

Published In

Abdom Radiol (NY)

DOI

EISSN

2366-0058

Publication Date

April 2021

Volume

46

Issue

4

Start / End Page

1607 / 1617

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Retrospective Studies
  • Prognosis
  • Pancreatic Neoplasms
  • Humans
  • Female
  • Carcinoma, Pancreatic Ductal
  • Adenocarcinoma