Mnemonic vulnerability induced by post-activation time-dependent new-learning.

Journal Article (Journal Article)

Reactivation renders consolidated memory labile again, and the ensuing temporary reconsolidation process is highly susceptible to mnemonic modification. Here, we show that memories in such an unstable state could be influenced by sheer behavioral means, bypassing the need for pharmacological intervention. Across several experiments using a "face-location association" paradigm in which participants experienced a "Learning - New-learning - Final-test" procedure, we demonstrate that reactivated memory traces were hampered when the new learning was strategically administered at between 0-min and 20-min delay. Using fMRI, we further advance our theoretical understanding that this lability can be mechanistically explained by the differential activation in the hippocampal-amygdala memory system implicated by the post-activation new-learning whereas the mnemonic intrusion caused by newly learned memories is efficaciously reconciled by the left inferior frontal gyrus.

Full Text

Duke Authors

Cited Authors

  • Shen, F; Chen, X; Li, J; Cao, W; Ku, Y; Wu, J; Cui, Y; Wang, Z; Wang, H; Kwok, SC

Published Date

  • October 2019

Published In

Volume / Issue

  • 164 /

Start / End Page

  • 107047 -

PubMed ID

  • 31325495

Electronic International Standard Serial Number (EISSN)

  • 1095-9564

International Standard Serial Number (ISSN)

  • 1074-7427

Digital Object Identifier (DOI)

  • 10.1016/j.nlm.2019.107047


  • eng