Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.

Journal Article (Journal Article)

Novel betulinic/betulonic acid-nucleoside hybrids were synthesized as possible new anti-HIV agents. Among the synthesized hybrids, two compounds were highly effective against HIV. Compared with AZT and DSB, compounds 10a (IC50 = 0.0078 μM, CC50 = 9.6 μM) and 10b (IC50 = 0.020 μM, CC50 = 23.8 μM) showed more potent or equipotent, respectively, anti-HIV activity but displayed lower cytotoxicity.

Full Text

Duke Authors

Cited Authors

  • Wang, Q; Li, Y; Zheng, L; Huang, X; Wang, Y; Chen, C-H; Cheng, Y-Y; Morris-Natschke, SL; Lee, K-H

Published Date

  • November 12, 2020

Published In

Volume / Issue

  • 11 / 11

Start / End Page

  • 2290 - 2293

PubMed ID

  • 33214842

Pubmed Central ID

  • PMC7667853

International Standard Serial Number (ISSN)

  • 1948-5875

Digital Object Identifier (DOI)

  • 10.1021/acsmedchemlett.0c00414

Language

  • eng

Conference Location

  • United States