Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.
Novel betulinic/betulonic acid-nucleoside hybrids were synthesized as possible new anti-HIV agents. Among the synthesized hybrids, two compounds were highly effective against HIV. Compared with AZT and DSB, compounds 10a (IC50 = 0.0078 μM, CC50 = 9.6 μM) and 10b (IC50 = 0.020 μM, CC50 = 23.8 μM) showed more potent or equipotent, respectively, anti-HIV activity but displayed lower cytotoxicity.
Wang, Q; Li, Y; Zheng, L; Huang, X; Wang, Y; Chen, C-H; Cheng, Y-Y; Morris-Natschke, SL; Lee, K-H
Volume / Issue
Start / End Page
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)