Antibiotics for Prophylaxis in the Setting of Preterm Prelabor Rupture of Membranes.

Journal Article (Journal Article;Review)

"For many years, providers have been using antibiotics to prevent infection in women who present with preterm prelabor rupture of membranes (PPROM). Given the polymicrobial nature of intra-amniotic infection, the recommended regimen includes a 7-day course of ampicillin and erythromycin, although many substitute of azithromycin. This regimen is used from viability to 34 weeks, independent of the number of fetuses present. Meta-analyses have shown that antibiotics for this indication are associated with lower rates of maternal and fetal infection, as well as longer pregnancy latency. Thus, latency antibiotics are recommended for all women with PPROM through 34 weeks of gestation."

Full Text

Duke Authors

Cited Authors

  • Dotters-Katz, S

Published Date

  • December 2020

Published In

Volume / Issue

  • 47 / 4

Start / End Page

  • 595 - 603

PubMed ID

  • 33121647

Electronic International Standard Serial Number (EISSN)

  • 1558-0474

Digital Object Identifier (DOI)

  • 10.1016/j.ogc.2020.08.005


  • eng

Conference Location

  • United States