Development of a straight vertebrate body axis.

Journal Article (Journal Article;Review)

The vertebrate body plan is characterized by the presence of a segmented spine along its main axis. Here, we examine the current understanding of how the axial tissues that are formed during embryonic development give rise to the adult spine and summarize recent advances in the field, largely focused on recent studies in zebrafish, with comparisons to amniotes where appropriate. We discuss recent work illuminating the genetics and biological mechanisms mediating extension and straightening of the body axis during development, and highlight open questions. We specifically focus on the processes of notochord development and cerebrospinal fluid physiology, and how defects in those processes may lead to scoliosis.

Full Text

Duke Authors

Cited Authors

  • Bagnat, M; Gray, RS

Published Date

  • October 6, 2020

Published In

Volume / Issue

  • 147 / 21

PubMed ID

  • 33023886

Pubmed Central ID

  • PMC7561478

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

Digital Object Identifier (DOI)

  • 10.1242/dev.175794


  • eng

Conference Location

  • England