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Development of a straight vertebrate body axis.

Publication ,  Journal Article
Bagnat, M; Gray, RS
Published in: Development (Cambridge, England)
October 2020

The vertebrate body plan is characterized by the presence of a segmented spine along its main axis. Here, we examine the current understanding of how the axial tissues that are formed during embryonic development give rise to the adult spine and summarize recent advances in the field, largely focused on recent studies in zebrafish, with comparisons to amniotes where appropriate. We discuss recent work illuminating the genetics and biological mechanisms mediating extension and straightening of the body axis during development, and highlight open questions. We specifically focus on the processes of notochord development and cerebrospinal fluid physiology, and how defects in those processes may lead to scoliosis.

Duke Scholars

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Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

October 2020

Volume

147

Issue

21

Start / End Page

dev175794

Related Subject Headings

  • Vertebrates
  • Spine
  • Scoliosis
  • Notochord
  • Morphogenesis
  • Body Patterning
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Bagnat, M., & Gray, R. S. (2020). Development of a straight vertebrate body axis. Development (Cambridge, England), 147(21), dev175794. https://doi.org/10.1242/dev.175794
Bagnat, Michel, and Ryan S. Gray. “Development of a straight vertebrate body axis.Development (Cambridge, England) 147, no. 21 (October 2020): dev175794. https://doi.org/10.1242/dev.175794.
Bagnat M, Gray RS. Development of a straight vertebrate body axis. Development (Cambridge, England). 2020 Oct;147(21):dev175794.
Bagnat, Michel, and Ryan S. Gray. “Development of a straight vertebrate body axis.Development (Cambridge, England), vol. 147, no. 21, Oct. 2020, p. dev175794. Epmc, doi:10.1242/dev.175794.
Bagnat M, Gray RS. Development of a straight vertebrate body axis. Development (Cambridge, England). 2020 Oct;147(21):dev175794.
Journal cover image

Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

October 2020

Volume

147

Issue

21

Start / End Page

dev175794

Related Subject Headings

  • Vertebrates
  • Spine
  • Scoliosis
  • Notochord
  • Morphogenesis
  • Body Patterning
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences