RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.

Journal Article (Journal Article;Review)

A major challenge in neurobiology in the 21st century is to understand how the brain adapts with experience. Activity-dependent gene expression is integral to the synaptic plasticity underlying learning and memory; however, this process cannot be explained by a simple linear trajectory of transcription to translation within a specific neuronal population. Many other regulatory mechanisms can influence RNA metabolism and the capacity of neurons to adapt. In particular, the RNA modification N6-methyladenosine (m6A) has recently been shown to regulate RNA processing through alternative splicing, RNA stability, and translation. Here, we discuss the emerging idea that m6A could also coordinate the transport, localization, and local translation of key mRNAs in learning and memory and expand on the notion of dynamic functional RNA states in the brain.

Full Text

Duke Authors

Cited Authors

  • Madugalle, SU; Meyer, K; Wang, DO; Bredy, TW

Published Date

  • December 2020

Published In

Volume / Issue

  • 43 / 12

Start / End Page

  • 1011 - 1023

PubMed ID

  • 33041062

Pubmed Central ID

  • PMC7688512

Electronic International Standard Serial Number (EISSN)

  • 1878-108X

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2020.09.005


  • eng

Conference Location

  • England