Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Obesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways involved with obesity and its relationship with cardiometabolic risk. This review will provide an overview of some of these important findings from both a biologic and clinical perspective. RECENT FINDINGS: Recent studies have identified polygenic risk scores and metabolomic biomarkers of obesity and related outcomes, which have also highlighted biological pathways, such as the branched-chain amino acid (BCAA) pathway that is dysregulated in this disease. These biomarkers may help in personalizing obesity interventions and for mitigation of future cardiometabolic risk. A multifaceted approach is necessary to impact the growing epidemic of obesity and related diseases. This will likely include incorporating precision medicine approaches with genomic and metabolomic biomarkers to personalize interventions and improve risk prediction.

Full Text

Duke Authors

Cited Authors

  • Regan, JA; Shah, SH

Published Date

  • October 10, 2020

Published In

Volume / Issue

  • 22 / 12

Start / End Page

  • 174 -

PubMed ID

  • 33040225

Pubmed Central ID

  • PMC8133795

Electronic International Standard Serial Number (EISSN)

  • 1534-3170

Digital Object Identifier (DOI)

  • 10.1007/s11886-020-01422-x


  • eng

Conference Location

  • United States