Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium.

Journal Article (Journal Article)

The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food and Drug Administration representatives, and industry members from the US and Europe. A series of meetings were convened to establish definitions and key concepts for the evaluation of HF therapies including optimal medical and device background therapy, clinical trial design elements and statistical concepts, and study endpoints. This manuscript summarizes the expert panel discussions as consensus recommendations focused on populations and endpoint definitions; it is not exhaustive or restrictive, but designed to stimulate HF clinical trial innovation.

Full Text

Duke Authors

Cited Authors

  • Abraham, WT; Psotka, MA; Fiuzat, M; Filippatos, G; Lindenfeld, J; Mehran, R; Ambardekar, AV; Carson, PE; Jacob, R; Januzzi, JL; Konstam, MA; Krucoff, MW; Lewis, EF; Piccini, JP; Solomon, SD; Stockbridge, N; Teerlink, JR; Unger, EF; Zeitler, EP; Anker, SD; O'Connor, CM

Published Date

  • December 2020

Published In

Volume / Issue

  • 22 / 12

Start / End Page

  • 2175 - 2186

PubMed ID

  • 33017862

Electronic International Standard Serial Number (EISSN)

  • 1879-0844

Digital Object Identifier (DOI)

  • 10.1002/ejhf.2018

Language

  • eng

Conference Location

  • England