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Phosphoproteomics for the masses.

Publication ,  Journal Article
Grimsrud, PA; Swaney, DL; Wenger, CD; Beauchene, NA; Coon, JJ
Published in: ACS Chem Biol
January 15, 2010

Protein phosphorylation serves as a primary mechanism of signal transduction in the cells of biological organisms. Technical advancements over the last several years in mass spectrometry now allow for the large-scale identification and quantitation of in vivo phosphorylation at unprecedented levels. These developments have occurred in the areas of sample preparation, instrumentation, quantitative methodology, and informatics so that today, 10 000-20 000 phosphorylation sites can be identified and quantified within a few weeks. With the rapid development and widespread availability of such data, its translation into biological insight and knowledge is a current obstacle. Here we present an overview of how this technology came to be and is currently applied, as well as future challenges for the field.

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Published In

ACS Chem Biol

DOI

EISSN

1554-8937

Publication Date

January 15, 2010

Volume

5

Issue

1

Start / End Page

105 / 119

Location

United States

Related Subject Headings

  • Signal Transduction
  • Proteomics
  • Proteome
  • Phosphorylation
  • Organic Chemistry
  • Humans
  • Animals
  • 34 Chemical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
 

Citation

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Grimsrud, P. A., Swaney, D. L., Wenger, C. D., Beauchene, N. A., & Coon, J. J. (2010). Phosphoproteomics for the masses. ACS Chem Biol, 5(1), 105–119. https://doi.org/10.1021/cb900277e
Grimsrud, Paul A., Danielle L. Swaney, Craig D. Wenger, Nicole A. Beauchene, and Joshua J. Coon. “Phosphoproteomics for the masses.ACS Chem Biol 5, no. 1 (January 15, 2010): 105–19. https://doi.org/10.1021/cb900277e.
Grimsrud PA, Swaney DL, Wenger CD, Beauchene NA, Coon JJ. Phosphoproteomics for the masses. ACS Chem Biol. 2010 Jan 15;5(1):105–19.
Grimsrud, Paul A., et al. “Phosphoproteomics for the masses.ACS Chem Biol, vol. 5, no. 1, Jan. 2010, pp. 105–19. Pubmed, doi:10.1021/cb900277e.
Grimsrud PA, Swaney DL, Wenger CD, Beauchene NA, Coon JJ. Phosphoproteomics for the masses. ACS Chem Biol. 2010 Jan 15;5(1):105–119.
Journal cover image

Published In

ACS Chem Biol

DOI

EISSN

1554-8937

Publication Date

January 15, 2010

Volume

5

Issue

1

Start / End Page

105 / 119

Location

United States

Related Subject Headings

  • Signal Transduction
  • Proteomics
  • Proteome
  • Phosphorylation
  • Organic Chemistry
  • Humans
  • Animals
  • 34 Chemical sciences
  • 31 Biological sciences
  • 06 Biological Sciences