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Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.

Publication ,  Journal Article
Dorismond, C; Hunter, SE; McNaull, PP; Zimmerman, KO; Benjamin, DK; Greenberg, RG; Corey, KM; Laughon, MM; Jackson, WM
Published in: J Perinatol
March 2021

OBJECTIVE: Characterize the types and doses of commonly administered perioperative drugs in inguinal hernia (IH) repair for premature infants. STUDY DESIGN: Single-center, retrospective cohort study. RESULTS: In total, 112 premature infants underwent IH repair between 2010 and 2015. Twenty-one drugs were used during IH repair, with each infant receiving a median seven drugs. Acetaminophen (88%), bupivacaine (84%), cisatracurium (74%), sevoflurane (72%), and propofol (71%) were the most commonly used agents. Thirty-two infants underwent additional procedures with IH repair. Additional procedures were not associated with a higher number of perioperative drugs, however infants with additional procedures were exposed to higher cumulative doses of cisatracurium (p < 0.001) and fentanyl (p = 0.002). CONCLUSION: There is wide variability in the drugs and doses used for a common surgical procedure in this population, even within a single center. Future research should focus on the safety and efficacy of the most commonly used perioperative drugs described in this study.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

March 2021

Volume

41

Issue

3

Start / End Page

577 / 581

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pharmaceutical Preparations
  • Pediatrics
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Herniorrhaphy
  • Hernia, Inguinal
 

Citation

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Dorismond, C., Hunter, S. E., McNaull, P. P., Zimmerman, K. O., Benjamin, D. K., Greenberg, R. G., … Jackson, W. M. (2021). Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants. J Perinatol, 41(3), 577–581. https://doi.org/10.1038/s41372-020-00864-z
Dorismond, Christina, Senyene E. Hunter, Peggy P. McNaull, Kanecia O. Zimmerman, Daniel K. Benjamin, Rachel G. Greenberg, Kristin M. Corey, Matthew M. Laughon, and Wesley M. Jackson. “Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.J Perinatol 41, no. 3 (March 2021): 577–81. https://doi.org/10.1038/s41372-020-00864-z.
Dorismond C, Hunter SE, McNaull PP, Zimmerman KO, Benjamin DK, Greenberg RG, et al. Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants. J Perinatol. 2021 Mar;41(3):577–81.
Dorismond, Christina, et al. “Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.J Perinatol, vol. 41, no. 3, Mar. 2021, pp. 577–81. Pubmed, doi:10.1038/s41372-020-00864-z.
Dorismond C, Hunter SE, McNaull PP, Zimmerman KO, Benjamin DK, Greenberg RG, Corey KM, Laughon MM, Jackson WM. Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants. J Perinatol. 2021 Mar;41(3):577–581.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

March 2021

Volume

41

Issue

3

Start / End Page

577 / 581

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pharmaceutical Preparations
  • Pediatrics
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Herniorrhaphy
  • Hernia, Inguinal