Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants.

Journal Article (Journal Article)

OBJECTIVE: Characterize the types and doses of commonly administered perioperative drugs in inguinal hernia (IH) repair for premature infants. STUDY DESIGN: Single-center, retrospective cohort study. RESULTS: In total, 112 premature infants underwent IH repair between 2010 and 2015. Twenty-one drugs were used during IH repair, with each infant receiving a median seven drugs. Acetaminophen (88%), bupivacaine (84%), cisatracurium (74%), sevoflurane (72%), and propofol (71%) were the most commonly used agents. Thirty-two infants underwent additional procedures with IH repair. Additional procedures were not associated with a higher number of perioperative drugs, however infants with additional procedures were exposed to higher cumulative doses of cisatracurium (p < 0.001) and fentanyl (p = 0.002). CONCLUSION: There is wide variability in the drugs and doses used for a common surgical procedure in this population, even within a single center. Future research should focus on the safety and efficacy of the most commonly used perioperative drugs described in this study.

Full Text

Duke Authors

Cited Authors

  • Dorismond, C; Hunter, SE; McNaull, PP; Zimmerman, KO; Benjamin, DK; Greenberg, RG; Corey, KM; Laughon, MM; Jackson, WM

Published Date

  • March 2021

Published In

Volume / Issue

  • 41 / 3

Start / End Page

  • 577 - 581

PubMed ID

  • 33097820

Pubmed Central ID

  • PMC7954820

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

Digital Object Identifier (DOI)

  • 10.1038/s41372-020-00864-z


  • eng

Conference Location

  • United States