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Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group.

Publication ,  Journal Article
Lautz, TB; Chi, Y-Y; Li, M; Wolden, SL; Casey, DL; Routh, JC; Granberg, CF; Binite, O; Rudzinski, ER; Hawkins, DS; Venkatramani, R; Rodeberg, DA
Published in: Cancer
January 15, 2021

BACKGROUND: Most children with intermediate-risk rhabdomyosarcoma (RMS) have gross disease (group III) at the initiation of chemotherapy. Delayed primary excision (DPE) after induction chemotherapy allows for a reduction in adjuvant radiation dose, but with the risk of potential surgical morbidity. The objectives of this study were to compare outcomes in children with group III RMS who did and did not undergo DPE and to assess surgical morbidity. METHODS: The study included 369 patients who had clinical group III RMS at sites amenable to DPE from intermediate-risk Children's Oncology Group studies D9803 (encouraged DPE) and ARST0531 (discouraged DPE). RESULTS: The primary tumor site was bladder/prostate (136 patients; 37%), extremity (97 patients; 26%), trunk (24 patients; 7%), retroperitoneum (91 patients; 25%), or intrathoracic/perineum/perianal (21 patients; 6%). In total, 112 patients (53.9%) underwent DPE in D9803, and 26 patients (16.2%) underwent DPE in ARST0531 (P < .001), with loss of vital organ or function in 30 of 138 patients (22%). DPE allowed for a reduced radiation dose in 110 of 135 patients (81%; 51% were reduced to 36 Gy, and 30% were reduced to 42 Gy). Patients who underwent DPE had improved unadjusted overall survival (P = .013). In adjusted regression analysis, the risk of death (hazard ratio, 0.71; 95% CI 0.43-1.16) was similar for patients who did and did not undergo DPE and was improved for the subset of patients who had tumors of the trunk and retroperitoneum (hazard ratio, 0.44; 95% CI, 0.20-0.97). CONCLUSIONS: Children with group III RMS have equivalent or improved outcomes with DPE and can receive a decreased radiation dose for definitive local control. The choice of local control modality should weigh the potential morbidity of surgery versus that of higher dose irradiation.

Duke Scholars

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

January 15, 2021

Volume

127

Issue

2

Start / End Page

275 / 283

Location

United States

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Treatment Failure
  • Time-to-Treatment
  • Rhabdomyosarcoma, Embryonal
  • Retroperitoneal Neoplasms
  • Radiotherapy, Adjuvant
  • Radiation Dosage
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Male
 

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Lautz, T. B., Chi, Y.-Y., Li, M., Wolden, S. L., Casey, D. L., Routh, J. C., … Rodeberg, D. A. (2021). Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer, 127(2), 275–283. https://doi.org/10.1002/cncr.33275
Lautz, Timothy B., Yueh-Yun Chi, Minjie Li, Suzanne L. Wolden, Dana L. Casey, Jonathan C. Routh, Candace F. Granberg, et al. “Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group.Cancer 127, no. 2 (January 15, 2021): 275–83. https://doi.org/10.1002/cncr.33275.
Lautz TB, Chi Y-Y, Li M, Wolden SL, Casey DL, Routh JC, et al. Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer. 2021 Jan 15;127(2):275–83.
Lautz, Timothy B., et al. “Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group.Cancer, vol. 127, no. 2, Jan. 2021, pp. 275–83. Pubmed, doi:10.1002/cncr.33275.
Lautz TB, Chi Y-Y, Li M, Wolden SL, Casey DL, Routh JC, Granberg CF, Binite O, Rudzinski ER, Hawkins DS, Venkatramani R, Rodeberg DA. Benefit of delayed primary excision in rhabdomyosarcoma: A report from the Children's Oncology Group. Cancer. 2021 Jan 15;127(2):275–283.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

January 15, 2021

Volume

127

Issue

2

Start / End Page

275 / 283

Location

United States

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Treatment Failure
  • Time-to-Treatment
  • Rhabdomyosarcoma, Embryonal
  • Retroperitoneal Neoplasms
  • Radiotherapy, Adjuvant
  • Radiation Dosage
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Male