An Open Resource for Non-human Primate Optogenetics.

Journal Article (Journal Article)

Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.

Full Text

Duke Authors

Cited Authors

  • Tremblay, S; Acker, L; Afraz, A; Albaugh, DL; Amita, H; Andrei, AR; Angelucci, A; Aschner, A; Balan, PF; Basso, MA; Benvenuti, G; Bohlen, MO; Caiola, MJ; Calcedo, R; Cavanaugh, J; Chen, Y; Chen, S; Chernov, MM; Clark, AM; Dai, J; Debes, SR; Deisseroth, K; Desimone, R; Dragoi, V; Egger, SW; Eldridge, MAG; El-Nahal, HG; Fabbrini, F; Federer, F; Fetsch, CR; Fortuna, MG; Friedman, RM; Fujii, N; Gail, A; Galvan, A; Ghosh, S; Gieselmann, MA; Gulli, RA; Hikosaka, O; Hosseini, EA; Hu, X; Hüer, J; Inoue, K-I; Janz, R; Jazayeri, M; Jiang, R; Ju, N; Kar, K; Klein, C; Kohn, A; Komatsu, M; Maeda, K; Martinez-Trujillo, JC; Matsumoto, M; Maunsell, JHR; Mendoza-Halliday, D; Monosov, IE; Muers, RS; Nurminen, L; Ortiz-Rios, M; O'Shea, DJ; Palfi, S; Petkov, CI; Pojoga, S; Rajalingham, R; Ramakrishnan, C; Remington, ED; Revsine, C; Roe, AW; Sabes, PN; Saunders, RC; Scherberger, H; Schmid, MC; Schultz, W; Seidemann, E; Senova, Y-S; Shadlen, MN; Sheinberg, DL; Siu, C; Smith, Y; Solomon, SS; Sommer, MA; Spudich, JL; Stauffer, WR; Takada, M; Tang, S; Thiele, A; Treue, S; Vanduffel, W; Vogels, R; Whitmire, MP; Wichmann, T; Wurtz, RH; Xu, H; Yazdan-Shahmorad, A; Shenoy, KV; DiCarlo, JJ; Platt, ML

Published Date

  • December 2020

Published In

Volume / Issue

  • 108 / 6

Start / End Page

  • 1075 - 1090.e6

PubMed ID

  • 33080229

Pubmed Central ID

  • PMC7962465

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2020.09.027

Language

  • eng