Neuroinflammation after surgery: from mechanisms to therapeutic targets.
Journal Article (Journal Article;Review)
Injury is a key driver of inflammation, a critical yet necessary response involving several mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous system can be triggered by a variety of stimuli, some intrinsic to the brain and others arising from peripheral signals. Fine-tuned regulation of this response is crucial in a system that is vulnerable due to, for example, aging and ongoing neurodegeneration. In this context, seemingly harmless interventions like a common surgery to repair a broken limb can overwhelm the immune system and become the driver of further complications such as delirium and other perioperative neurocognitive disorders. Here, we discuss potential mechanisms by which the immune system affects the central nervous system after surgical trauma. Together, these neuroimmune interactions are becoming hallmarks of and potential therapeutic targets for multiple neurologic conditions, including those affecting the perioperative space.
Full Text
Duke Authors
Cited Authors
- Yang, T; Velagapudi, R; Terrando, N
Published Date
- November 2020
Published In
Volume / Issue
- 21 / 11
Start / End Page
- 1319 - 1326
PubMed ID
- 33077953
Pubmed Central ID
- PMC7704062
Electronic International Standard Serial Number (EISSN)
- 1529-2916
Digital Object Identifier (DOI)
- 10.1038/s41590-020-00812-1
Language
- eng
Conference Location
- United States