Neuroinflammation after surgery: from mechanisms to therapeutic targets.

Journal Article (Journal Article;Review)

Injury is a key driver of inflammation, a critical yet necessary response involving several mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous system can be triggered by a variety of stimuli, some intrinsic to the brain and others arising from peripheral signals. Fine-tuned regulation of this response is crucial in a system that is vulnerable due to, for example, aging and ongoing neurodegeneration. In this context, seemingly harmless interventions like a common surgery to repair a broken limb can overwhelm the immune system and become the driver of further complications such as delirium and other perioperative neurocognitive disorders. Here, we discuss potential mechanisms by which the immune system affects the central nervous system after surgical trauma. Together, these neuroimmune interactions are becoming hallmarks of and potential therapeutic targets for multiple neurologic conditions, including those affecting the perioperative space.

Full Text

Duke Authors

Cited Authors

  • Yang, T; Velagapudi, R; Terrando, N

Published Date

  • November 2020

Published In

Volume / Issue

  • 21 / 11

Start / End Page

  • 1319 - 1326

PubMed ID

  • 33077953

Pubmed Central ID

  • PMC7704062

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

Digital Object Identifier (DOI)

  • 10.1038/s41590-020-00812-1

Language

  • eng

Conference Location

  • United States