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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.

Publication ,  Journal Article
Cardones, AR
Published in: Clin Dermatol
2020

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous drug reaction characterized by fever, lymphadenopathy, hematologic abnormalities, multisystem involvement, and viral reactivation. Although most patients with DRESS syndrome are able to fully recover, a subset of patients go on to have a prolonged course with recurrence, and/or autoimmune complications. Severe systemic involvement is associated with significant morbidity and mortality. Viral reactivation, especially of human herpes virus 6, Epstein-Barr virus, and cytomegalovirus, is a common feature of DRESS, with a high viral load and antibody titers being associated with poor outcomes. Aside from prompt discontinuation of the offending drug, treatment for patients with significant disease consists of systemic therapy with corticosteroids.

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Published In

Clin Dermatol

DOI

EISSN

1879-1131

Publication Date

2020

Volume

38

Issue

6

Start / End Page

702 / 711

Location

United States

Related Subject Headings

  • Virus Activation
  • Viral Load
  • Severity of Illness Index
  • Prognosis
  • Pharmaceutical Preparations
  • Male
  • Humans
  • Herpesvirus 6, Human
  • Herpesvirus 4, Human
  • Female
 

Citation

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Cardones, A. R. (2020). Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clin Dermatol, 38(6), 702–711. https://doi.org/10.1016/j.clindermatol.2020.06.008
Cardones, Adela R. “Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.Clin Dermatol 38, no. 6 (2020): 702–11. https://doi.org/10.1016/j.clindermatol.2020.06.008.
Cardones AR. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clin Dermatol. 2020;38(6):702–11.
Cardones, Adela R. “Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.Clin Dermatol, vol. 38, no. 6, 2020, pp. 702–11. Pubmed, doi:10.1016/j.clindermatol.2020.06.008.
Cardones AR. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clin Dermatol. 2020;38(6):702–711.
Journal cover image

Published In

Clin Dermatol

DOI

EISSN

1879-1131

Publication Date

2020

Volume

38

Issue

6

Start / End Page

702 / 711

Location

United States

Related Subject Headings

  • Virus Activation
  • Viral Load
  • Severity of Illness Index
  • Prognosis
  • Pharmaceutical Preparations
  • Male
  • Humans
  • Herpesvirus 6, Human
  • Herpesvirus 4, Human
  • Female