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Matrix metalloproteinase 9 positivity predicts long term decreased tear production.

Publication ,  Journal Article
Soifer, M; Mousa, HM; Stinnett, SS; Galor, A; Perez, VL
Published in: Ocul Surf
January 2021

PURPOSE: To investigate long-term correlations between Matrix Metalloproteinase-9 (MMP-9) testing and dry eye (DE) parameters. Additionally, to evaluate variability in MMP-9 results over time and with anti-inflammatory treatment. METHODS: Retrospective cohort study of DE patients with equal MMP-9 testing results (positive or negative) in both eyes and a minimum of 6 months of follow up. Our main outcome measure was to examine whether initial MMP-9 status affected change in DE parameters over time. Secondarily, we evaluated the frequency of MMP-9 status change over time and examined whether MMP-9 status change was impacted by treatment. RESULTS: 67 patients (76% female) fit the inclusion criteria. Mean age was 63 years with a mean follow up of 10.6 months. The majority (37/67, 55%) had concomitant systemic immune disease. MMP-9 testing was positive in both eyes in 39 individuals (58%) and negative in both eyes in 27 (42%) individuals. Of all DE parameters, initial MMP status predicted change in tear production. Individuals in the MMP-9 positive group had a greater decrease in production from baseline to final visit compared to the negative group (-2.6 vs 2.1, P = 0.013). In those initially MMP-9 positive, the frequency of becoming MMP-9 negative was higher in eyes treated with anti-inflammatory therapy compared to artificial tears (22.9% vs 3.3%, P = 0.106). However, only Lifitegrast 5% showed statistical significance compared to artificial tears (31.3% vs 3.3%, P = 0.044). CONCLUSIONS: Eyes with detectable MMP-9 had significantly decreased tear production over time compared to those without detectable MMP-9. Anti-inflammatory treatment more frequently normalized MMP-9 compared to PFATs.

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Published In

Ocul Surf

DOI

EISSN

1937-5913

Publication Date

January 2021

Volume

19

Start / End Page

270 / 274

Location

United States

Related Subject Headings

  • Tears
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Matrix Metalloproteinase 9
  • Male
  • Lubricant Eye Drops
  • Humans
  • Female
  • Dry Eye Syndromes
 

Citation

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Soifer, M., Mousa, H. M., Stinnett, S. S., Galor, A., & Perez, V. L. (2021). Matrix metalloproteinase 9 positivity predicts long term decreased tear production. Ocul Surf, 19, 270–274. https://doi.org/10.1016/j.jtos.2020.10.003
Soifer, Matias, Hazem M. Mousa, Sandra S. Stinnett, Anat Galor, and Victor L. Perez. “Matrix metalloproteinase 9 positivity predicts long term decreased tear production.Ocul Surf 19 (January 2021): 270–74. https://doi.org/10.1016/j.jtos.2020.10.003.
Soifer M, Mousa HM, Stinnett SS, Galor A, Perez VL. Matrix metalloproteinase 9 positivity predicts long term decreased tear production. Ocul Surf. 2021 Jan;19:270–4.
Soifer, Matias, et al. “Matrix metalloproteinase 9 positivity predicts long term decreased tear production.Ocul Surf, vol. 19, Jan. 2021, pp. 270–74. Pubmed, doi:10.1016/j.jtos.2020.10.003.
Soifer M, Mousa HM, Stinnett SS, Galor A, Perez VL. Matrix metalloproteinase 9 positivity predicts long term decreased tear production. Ocul Surf. 2021 Jan;19:270–274.
Journal cover image

Published In

Ocul Surf

DOI

EISSN

1937-5913

Publication Date

January 2021

Volume

19

Start / End Page

270 / 274

Location

United States

Related Subject Headings

  • Tears
  • Retrospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Matrix Metalloproteinase 9
  • Male
  • Lubricant Eye Drops
  • Humans
  • Female
  • Dry Eye Syndromes