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Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.

Publication ,  Journal Article
Hoye, ML; Silver, DL
Published in: Curr Opin Neurobiol
February 2021

Regulation of stem cell fate decisions is elemental to faithful development, homeostasis, and organismal fitness. Emerging data demonstrate pluripotent stem cells exhibit a vast transcriptional landscape, which is refined as cells differentiate. In the developing neocortex, transcriptional priming of neural progenitors, coupled with post-transcriptional control, is critical for defining cell fates of projection neurons. In particular, radial glial progenitors exhibit dynamic post-transcriptional regulation, including subcellular mRNA localization, RNA decay, and translation. These processes involve both cis-regulatory and trans-regulatory factors, many of which are implicated in neurodevelopmental disease. This review highlights emerging post-transcriptional mechanisms which govern cortical development, with a particular focus on translational control of neuronal fates, including those relevant for disease.

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Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

February 2021

Volume

66

Start / End Page

93 / 102

Location

England

Related Subject Headings

  • Neurons
  • Neurogenesis
  • Neocortex
  • Gene Expression Regulation, Developmental
  • Cell Differentiation
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

Citation

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Hoye, M. L., & Silver, D. L. (2021). Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate. Curr Opin Neurobiol, 66, 93–102. https://doi.org/10.1016/j.conb.2020.10.001
Hoye, Mariah L., and Debra L. Silver. “Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.Curr Opin Neurobiol 66 (February 2021): 93–102. https://doi.org/10.1016/j.conb.2020.10.001.
Hoye, Mariah L., and Debra L. Silver. “Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.Curr Opin Neurobiol, vol. 66, Feb. 2021, pp. 93–102. Pubmed, doi:10.1016/j.conb.2020.10.001.
Journal cover image

Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

February 2021

Volume

66

Start / End Page

93 / 102

Location

England

Related Subject Headings

  • Neurons
  • Neurogenesis
  • Neocortex
  • Gene Expression Regulation, Developmental
  • Cell Differentiation
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences