Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.
Journal Article (Journal Article;Review)
Regulation of stem cell fate decisions is elemental to faithful development, homeostasis, and organismal fitness. Emerging data demonstrate pluripotent stem cells exhibit a vast transcriptional landscape, which is refined as cells differentiate. In the developing neocortex, transcriptional priming of neural progenitors, coupled with post-transcriptional control, is critical for defining cell fates of projection neurons. In particular, radial glial progenitors exhibit dynamic post-transcriptional regulation, including subcellular mRNA localization, RNA decay, and translation. These processes involve both cis-regulatory and trans-regulatory factors, many of which are implicated in neurodevelopmental disease. This review highlights emerging post-transcriptional mechanisms which govern cortical development, with a particular focus on translational control of neuronal fates, including those relevant for disease.
Full Text
Duke Authors
Cited Authors
- Hoye, ML; Silver, DL
Published Date
- February 2021
Published In
Volume / Issue
- 66 /
Start / End Page
- 93 - 102
PubMed ID
- 33130411
Pubmed Central ID
- PMC8058166
Electronic International Standard Serial Number (EISSN)
- 1873-6882
Digital Object Identifier (DOI)
- 10.1016/j.conb.2020.10.001
Language
- eng
Conference Location
- England