Decoding mixed messages in the developing cortex: translational regulation of neural progenitor fate.

Journal Article (Journal Article;Review)

Regulation of stem cell fate decisions is elemental to faithful development, homeostasis, and organismal fitness. Emerging data demonstrate pluripotent stem cells exhibit a vast transcriptional landscape, which is refined as cells differentiate. In the developing neocortex, transcriptional priming of neural progenitors, coupled with post-transcriptional control, is critical for defining cell fates of projection neurons. In particular, radial glial progenitors exhibit dynamic post-transcriptional regulation, including subcellular mRNA localization, RNA decay, and translation. These processes involve both cis-regulatory and trans-regulatory factors, many of which are implicated in neurodevelopmental disease. This review highlights emerging post-transcriptional mechanisms which govern cortical development, with a particular focus on translational control of neuronal fates, including those relevant for disease.

Full Text

Duke Authors

Cited Authors

  • Hoye, ML; Silver, DL

Published Date

  • February 2021

Published In

Volume / Issue

  • 66 /

Start / End Page

  • 93 - 102

PubMed ID

  • 33130411

Pubmed Central ID

  • PMC8058166

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2020.10.001

Language

  • eng

Conference Location

  • England